Levosimendan Following Cardiac Surgery

被引：4
|
作者：
Conte, Sean M. [1 ]
Florisson, Daniel S. [1 ]
De Bono, Joshua A. [1 ]
Davies, Reece A. [1 ]
Newcomb, Andrew E. [1 ]
机构：
[1] St Vincents Hosp Melbourne, Cardiothorac Surg Dept, Melbourne, Vic, Australia
来源：
HEART LUNG AND CIRCULATION | 2019年 / 28卷 / 03期
关键词：
Review; Levosimendan; Cardiac surgery; Perioperative; METAANALYSIS;
D O I：
10.1016/j.hlc.2018.02.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A best evidence topic was written to address if perioperative levosimendan improves mortality following cardiac surgery. Fourteen papers represented the best available evidence. An older meta-analysis summarising 11 of these trials concluded that there were fewer deaths in the levosimendan group compared to the control group (OR 0.41, p < 0.001) however, this was driven by the results of three included trials by the same author. Three larger and more recent randomised controlled trials failed to demonstrate significant differences in mortality. We conclude that levosimendan lacks robust evidence to substantiate claims of mortality benefit in cardiac surgery patients and should not be used routinely in such patients.
引用
收藏
页码：E19 / E20
页数：2
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