Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer

被引：0
|
作者：
Gomendio, B
Silva, JM
Provencio, M
Garcia, JM
GarciaPatino, E
GarciaAndrade, C
Carretero, L
Espana, P
Bonilla, F
机构：
[1] CLIN TRABAJO,MOL GENET UNIT,MADRID 28003,SPAIN
[2] CLIN PUERTA DE HIERRO,DEPT MED ONCOL,MADRID 28035,SPAIN
[3] HOSP SANTA CRISTINA,DEPT PATHOL,E-28009 MADRID,SPAIN
[4] HOSP GEN GREGORIO MARANON,DEPT PATHOL,MADRID 28009,SPAIN
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1997年 / 10卷 / 03期
关键词：
loss of heterozygosity; breast cancer; BRCA1; locus; 17q21; region; prognostic factors;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sporadic breast cancer is the commonest form of this malignancy. Genetic changes are frequent events in breast cancer. We investigated the implication of LOH in the 17q21 region as a prognostic factor in this disease. Fifty-three patients were studied and 14 clinico-pathological parameters were evaluated for comparison between the patients with LOH and patients without LOH. A LOH rate of 21% was found and, upon comparison of the two subgroups, a significantly lower rate of recurrence after adjuvant chemotherapy in patients with LOH was observed. This suggests that LOH occurring in this region in breast cancer could help to design new adjuvant treatment strategies.
引用
收藏
页码：659 / 663
页数：5
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