A striking periodicity of the cis/trans isomerization of proline imide bonds in cyclic disulfide-bridged peptides

被引：32

作者：

Shi, T ^{[1
]}

Spain, SM ^{[1
]}

Rabenstein, DL ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 11期

关键词：

disulfide peptides; isomerization; NMR spectroscopy; peptides; proline;

D O I：

10.1002/anie.200503470

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) cis persists: The population of the cis conformation of the Cys-Pro imide bond of the cyclic disulfide form of peptides of the sequence Ac-Cys-Pro-(Xaa)m-Cys-NH2 (Xaa = Phe, Ala) ranges from 9.3 to 76.9% and shows a striking periodic dependence on the number of residues in the peptide. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1780 / 1783

页数：4