Working and reference memory in seizure-prone and seizure-resistant rats: Impact of amygdala kindling

In rat selectively bred for different amygdala kindling rates (Fast vs. Slow), comorbid differences in learning were detected. Here, performance was tested in a delayed alternation task before, during, and after kindling. Although similar reference memory was evident, Fast rats showed working memory deficits with increasing delays between information and choice trials. Further, seizures shortly before learning disrupted both reference and working memory in Fast, but not Slow, rats. Weeks after kindling, progressive delays further disrupted Fast rats, but only longer delays disrupted Slow rats. Clearly relevant to individual differences in human epilepsy, a temporal lobe, seizure-prone genetic background in rats provides poorer original learning and easier disruption of new learning by recent and past seizures than a seizure-resistant background.