Investigation of a Lomentospora prolificans case cluster with whole genome sequencing

被引：8
|
作者：
Boan, Peter [1 ,2 ]
Pang, Stanley [3 ]
Gardam, Dianne J. [2 ]
Darragh, Helen [2 ]
Wright, Matthew [1 ,2 ]
Coombs, Geoffrey W. [2 ,3 ]
机构：
[1] Fiona Stanley Hosp, 11 Robin Warren Ave, Perth, WA 6150, Australia
[2] PathWest Lab Med WA, 11 Robin Warren Ave, Perth, WA 6150, Australia
[3] Murdoch Univ, 90 South St, Perth, WA 6150, Australia
来源：
MEDICAL MYCOLOGY CASE REPORTS | 2020年 / 29卷
关键词：
Lomentospora prolificans; Scedosporium prolificans; Fungal outbreak; Whole genome sequencing; Antifungal resistance; SCEDOSPORIUM; MILTEFOSINE; VORICONAZOLE; COMBINATION; INFECTION; OUTBREAK;
D O I：
10.1016/j.mmcr.2020.05.003
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lomentospora prolificans has caused outbreaks in immunocompromised patients. We performed whole genome sequencing (WGS) on 4 L. prolificans isolates from infections occurring during an 8-month period in the haematology unit at Hospital 1., and 2 isolates from unrelated infections at Hospital 2., showing a high number of mutational differences (> 10,000 single nucleotide polymorphisms) between L. prolificans isolates from Hospital 1. Novel typing of isolates by WGS did not demonstrate a single causative strain.
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页码：1 / 4
页数：4
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