Long-term preservation of cortically dependent visual function in RCS rats by transplantation

被引：167
|
作者：
Coffey, PJ
Girman, S
Wang, SM
Hetherington, L
Keegan, DJ
Adamson, P
Greenwood, J
Lund, RD [1 ]
机构：
[1] Univ Utah, Moran Eye Ctr, Dept Ophthalmol, Salt Lake City, UT 84132 USA
[2] Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England
[3] Univ Coll, Inst Ophthalmol, London EC1V 9EL, England
来源：
NATURE NEUROSCIENCE | 2002年 / 5卷 / 01期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/nn782
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cell transplantation is one way of limiting the progress of retinal degeneration in animal models of blinding diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Here we transplanted a human retinal pigment epithelia] (RPE) cell line into the subretinal space of one such model, the Royal College of Surgeons (RCS) rat, and showed, using head tracking to moving stripes and pattern discrimination in conjunction with single-unit cortical physiology, that cortically mediated vision can be preserved with this treatment.
引用
收藏
页码：53 / 56
页数：4
相关论文
共 50 条
  • [31] VISUAL IMPROVEMENT AFTER LONG-TERM SUCCESS OF PANCREATIC TRANSPLANTATION
    FRIBERG, TR
    TZAKIS, AG
    CARROLL, PB
    STARZL, TE
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 1990, 110 (05) : 564 - 565
  • [32] Effect of Long-Term Treatment of L-Ornithine on Visual Function and Retinal Histology in the Rats
    Sakamoto, Kenji
    Mori, Asami
    Nakahara, Tsutomu
    Morita, Masahiko
    Ishii, Kunio
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, 38 (01) : 139 - 143
  • [33] Long-term preservation of the vasculature
    Ingemansson, R
    COMPROMISED PERFUSION, 1996, 22 : 81 - 87
  • [34] LONG-TERM PRESERVATION OF BLOOD
    LEHMANN, H
    ROBSON, DC
    WHITCHER, HW
    MACFARLANE, LRS
    PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1964, 57 (07): : 625 - 634
  • [35] LONG-TERM PANCREAS PRESERVATION
    WAHLBERG, JA
    CRYOBIOLOGY, 1986, 23 (06) : 568 - 568
  • [36] LONG-TERM PRESERVATION OF STREPTOCOCCI
    BRAHMADATHAN, KN
    PANDIAN, R
    KOSHI, G
    INDIAN JOURNAL OF MEDICAL RESEARCH, 1995, 101 : 64 - 65
  • [37] LONG-TERM PRESERVATION OF BLOOD
    MOORE, CV
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1960, 173 (15): : 1668 - 1668
  • [38] EFFECTS OF ISLET TRANSPLANTATION ON RENAL-FUNCTION AND MORPHOLOGY OF SHORT-TERM AND LONG-TERM DIABETIC RATS
    WEBER, CJ
    SILVA, FG
    HARDY, MA
    PIRANI, CL
    REEMTSMA, K
    TRANSPLANTATION PROCEEDINGS, 1979, 11 (01) : 549 - 556
  • [39] Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells
    Min, JY
    Yang, YK
    Sullivan, MF
    Ke, QE
    Converso, KL
    Chen, Y
    Morgan, JP
    Xiao, YF
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 125 (02): : 361 - 369
  • [40] LONG-TERM RESCUE OF PHOTORECEPTOR CELLS IN THE RETINAS OF RCS DYSTROPHIC RATS BY RPE TRANSPLANTS
    LI, LX
    SHEEDLO, HJ
    TURNER, JE
    PROGRESS IN BRAIN RESEARCH, 1990, 82 : 179 - 185
12345