Interacting Partners of AMPA-Type Glutamate Receptors

被引：12
|
作者：
Cheng, Juan [1 ,2 ]
Dong, Jie [1 ]
Cui, Yaxuan [1 ]
Wang, Liecheng [2 ]
Wu, Bei [1 ]
Zhang, Chen [1 ]
机构：
[1] Peking Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
[2] Anhui Med Univ, Dept Physiol, Hefei 230032, Anhui, Peoples R China
来源：
JOURNAL OF MOLECULAR NEUROSCIENCE | 2012年 / 48卷 / 02期
关键词：
AMPA receptors; Protein-protein interactions; Synapses; DOMAIN-CONTAINING PROTEIN; LONG-TERM DEPRESSION; SYNAPTIC PLASTICITY; EXCITATORY SYNAPSES; DENDRITIC SPINES; HIPPOCAMPAL-NEURONS; SURFACE EXPRESSION; NSF BINDING; C-TERMINUS; STARGAZIN;
D O I：
10.1007/s12031-012-9724-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutamate is the principal excitatory neurotransmitter in the brain. The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic (AMPA) receptors, as one of several types of endogenous ionotropic glutamate receptors, mediate the fast excitatory synaptic transmission that is essential for information processing and integration in the mammalian brain. Modifications of AMPA receptors are assumed to be the molecular basis underlying learning and memory, and impairments of AMPA receptors cause certain neurological diseases, including epilepsy, autism spectrum disorders, and Alzheimer's disease. Thus, extensive studies have been conducted, and these have revealed a complex protein-protein network controlling the expression, trafficking, and function of AMPA receptors in neurons. Here, we summarize the interacting partners of AMPA-type glutamate receptors and the functional implications of these interactions.
引用
收藏
页码：441 / 447
页数：7
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