Highly Enantioselective Synthesis of Tetrahydrocarbolines via Iridium-Catalyzed Intramolecular Friedel-Crafts Type Allylic Alkylation Reactions

被引：34
|
作者：
Xu, Qing-Long [1 ]
Zhuo, Chun-Xiang [1 ]
Dai, Li-Xin [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 23期
基金：
中国国家自然科学基金;
关键词：
KINETIC ASYMMETRIC TRANSFORMATIONS; INDOLES; ALLYLATION; ALCOHOLS; PYRROLES; TETRAHYDROISOQUINOLINES; FUNCTIONALIZATION; DEAROMATIZATION; CONSTRUCTION; ACCESS;
D O I：
10.1021/ol4027717
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective synthesis of substituted tetrahydrocarbolines via Ir-catalyzed Friedel-Crafts type intramolecular asymmetric allylic alkylation of 2-indolyl allyl carbonates has been developed. This strategy features excellent chemoselectivity and enantioselectivity, mild reaction conditions, and an easily accessed chiral ligand.
引用
收藏
页码：5909 / 5911
页数：3
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