Acetaminophen synthesis and encapsulation using safe mixed-solvents and solution enhanced dispersion by supercritical CO2

被引:2
|
作者
Islam, Tariqul [1 ]
Sarker, Md Zaidul Islam [1 ,2 ]
Uddin, Abm Helal [1 ]
Smith, Richard Lee, Jr. [3 ]
机构
[1] Int Islamic Univ Malaysia, Fac Pharm, Kuantan 25200, Pahang, Malaysia
[2] Northern Marianas Coll, Program Leader Food Sci Program, Cooperat Res Extens & Educ Serv, Saipan, CM 96950 USA
[3] Tohoku Univ, Grad Sch Environm Studies, Aoba Ku, Ararnaki Aza Aoba 6-6-11, Sendai, Miyagi 9808579, Japan
来源
JOURNAL OF SUPERCRITICAL FLUIDS | 2022年 / 188卷
关键词
Pharmaceuticals; Amide coupling reaction; Paracetamol; Mixed-solvent SEDS; Encapsulation; CARBON-DIOXIDE; PARACETAMOL; CRYSTALLIZATION; COPRECIPITATION; SOLUBILITY; DELIVERY; ACID; FORM;
D O I
10.1016/j.supflu.2022.105669
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Acetaminophen (ACMP) was synthesized in mixed-solvents (H2O-acetone, H2O-dimethyl sulfoxide, H2O-isopropyl alcohol) for purposes of eliminating hazardous dipolar aprotic solvents. The H2O-acetone solvent-pair gave synthesized ACMP yields of 79.2%. Synthesized ACMP samples were encapsulated using solution enhanced dispersion by supercritical CO2 (SEDS) at 150 bar, 45 degrees C, 1.5 mL/min feed flow rate (30 mg ACMP/mL in mixed-solvent), CO2 flow rate of 15 L/min (1 bar, 25 degrees C) in which suitable products could not be formed with PEG-4000 excipient at ACMP:PEG ratios of 1:1 with mixed-solvents, however, with ethyl cellulose (EC) excipient at ACMP:EC ratios of 1:1 and ethanol-acetone mixed-solvent (x:y, v/v, x = 1-9, y = 9-1), encapsulated products could be formed over the full range of mixed-solvent compositions. ACMP encapsulated fine particles had purities as high as 99.9% demonstrating that SEDS with safe mixed-solvents can broaden methods available for encapsulating pharmaceuticals.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Preparation and characterization of paclitaxel loaded PLLA-PEG-PLLA nanoparticles for controlled release of anticancer drugs using solution-enhanced dispersion in supercritical CO2
    Zhao, Zheng
    Zhang, Yu
    Chen, Ai-Zheng
    Li, Yi
    Liu, Xuan
    Li, Jia-Shen
    Zheng, Zi-Jian
    JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) : E94 - E95
  • [42] Extraction of bioactive lipids from Pleuroncodes monodon using organic solvents and supercritical CO2
    Barriga-Sanchez, M.
    Sanchez-Gonzales, G.
    Condori, M. A. Varas
    Alvites, M. N. Sanjinez
    De Valenzuela, M. E. Ayala Galdos
    GRASAS Y ACEITES, 2023, 74 (01)
  • [43] Influence of co-solvents on fucoxanthin and phlorotannin recovery from brown seaweed using supercritical CO2
    Saravana, Periaswamy Sivagnanam
    Getachewac, Adane Tilahun
    Cho, Yeon-Jin
    Choi, Jae Hyung
    Park, Yong Beom
    Woo, Hee Chul
    Chun, Byung Soo
    JOURNAL OF SUPERCRITICAL FLUIDS, 2017, 120 : 295 - 303
  • [44] Co-precipitation of trans-resveratrol in PHBV using Solution Enhanced Dispersion by Supercritical Fluids technique
    Dal Magro, Camila
    Aguiar, Gean P. S.
    Veneral, Josamaique G.
    dos Santos, Aline E.
    de Chaves, Lorenzo M. P. C.
    Vladimir Oliveira, J.
    Lanza, Marcelo
    JOURNAL OF SUPERCRITICAL FLUIDS, 2017, 127 : 182 - 190
  • [45] Preparation and Characterization of Paclitaxel Loaded SF/PLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2
    Zhao, Zheng
    Li, Yi
    Zhang, Yu
    JOURNAL OF NANOMATERIALS, 2015, 2015
  • [46] CO2 Capture Using Amine Solution Mixed with Ionic Liquid
    Yang, Jie
    Yu, Xinhai
    Yan, Jinyue
    Tu, Shan-Tung
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2014, 53 (07) : 2790 - 2799
  • [47] Lysozyme encapsulation within PLGA and CaCO3 microparticles using supercritical CO2 medium
    Tran, M. -K.
    Hassani, L. N.
    Calvignac, B.
    Beuvier, T.
    Hindre, F.
    Boury, F.
    JOURNAL OF SUPERCRITICAL FLUIDS, 2013, 79 : 159 - 169
  • [48] Encapsulation of astaxanthin from Haematococcus pluvialis in PHBV by means of SEDS technique using supercritical CO2
    Machado, Francisco R. S., Jr.
    Reis, Daiane F.
    Boschetto, Daiane L.
    Burkert, Janaina F. M.
    Ferreira, Sandra R. S.
    Oliveira, J. Vladimir
    Burkert, Carlos Andre V.
    INDUSTRIAL CROPS AND PRODUCTS, 2014, 54 : 17 - 21
  • [49] Photoreduction of CO2 Using [Ru(bpy)2(CO)L]n+ Catalysts in Biphasic Solution/Supercritical CO2 Systems
    Voyame, Patrick
    Toghill, Kathryn E.
    Mendez, Manuel A.
    Girault, Hubert H.
    INORGANIC CHEMISTRY, 2013, 52 (19) : 10949 - 10957
  • [50] Melting point depression by using supercritical CO2 for a novel melt dispersion micronization process
    Dohrn, R.
    Bertakis, E.
    Behrend, O.
    Voutsas, E.
    Tassios, D.
    JOURNAL OF MOLECULAR LIQUIDS, 2007, 131 (SPEC. ISS.) : 53 - 59