Synthesis and applications of silicon-containing α-amino acids

被引：149

作者：

Mortensen, Matthew ^{[1
]}

Husmann, Ralph ^{[1
]}

Veri, Elisabetta ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Univ Aachen, Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 04期

关键词：

BUILDING FUNCTIONALIZED PEPTIDOMIMETICS; UND SILAZAN-CARBONSAUREESTER; N-ACYLIMINIUM IONS; ASYMMETRIC-SYNTHESIS; C/SI/GE BIOISOSTERISM; ENZYMATIC PREPARATION; HYDROXYACETIC ACIDS; PEPTIDES; SILAPROLINE; PROLINE;

D O I：

10.1039/b816769a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amino acids serve not only as monomers for proteins and enzymes but also as important players in signal transduction pathways. They belong to the abundant feedstock of the pharmaceutical, food science and agrochemical industries, and some are used as catalysts or ligand components. In recent years, non-proteogenic amino acids have taken on important roles. This tutorial review summarises the progress in the development of strategies to construct silicon-containing alpha-amino acid frameworks and the studies concerned with their structure and activity. It shall be of interest for the synthesis and biosciences communities.

引用

页码：1002 / 1010

页数：9

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