STALing B cell responses with CD22

被引：3
|
作者：
Chappell, Craig P. [1 ]
Clark, Edward A. [1 ]
机构：
[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 07期
关键词：
PLASMACYTOID DENDRITIC CELLS; ANTIGEN DELIVERY; FACTOR-VIII; T-CELL; ENHANCEMENT; SIGNALS;
D O I：
10.1172/JCI69670
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Suppressing unwanted humoral immune responses without compromising the host's ability to respond to foreign pathogens is a primary goal for therapies aimed at ameliorating harmful autoantibody production. Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can have off-target effects, a limitation to conventional therapies. In this issue of the JCI, Macauley and colleagues utilize a novel platform to inhibit antigen-specific antibody production that preserves the immune system's ability to respond to unrelated antigens.
引用
收藏
页码：2778 / 2780
页数：3
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