Co-expression of PDGF-B and VEGFR-3 strongly correlates with poor prognosis in hepatocellular carcinoma patients after hepatectomy

被引：15
|
作者：
Chen, Bin [1 ]
Liu, Jinghua [2 ]
Wang, Xionghua [1 ]
Shen, Qian [1 ]
Li, Chao [1 ]
Dai, Chunshan [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Affiliated Ningbo Tradit Chinese Med Hosp, Dept Gen Surg, Ningbo 315010, Zhejiang, Peoples R China
[2] Linyi Peoples Hosp, Dept Hepatobiliary Surg, 27th East Jiefang Rd, Linyi 276000, Shandong, Peoples R China
来源：
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2018年 / 42卷 / 02期
关键词：
CELL LUNG-CANCER; ENDOTHELIAL GROWTH-FACTOR; STROMAL CELLS; LYMPHATIC METASTASIS; FLT4; RECEPTOR; FACTOR-C; LYMPHANGIOGENESIS; TUMOR; ANGIOGENESIS; EXPRESSION;
D O I：
10.1016/j.clinre.2016.11.006
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) patients following hepatectomy with biological markers is of great importance. Methods: In this study, we collected samples from 90 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of PDGF-B and VEGFR-3 in these HCC samples. Results: According to the immunohistochemical results, PDGF-B and VEGFR-3 staining were significantly associated with clinical features. Additionally, a significant association between high PDGF-B and VEGFR-3 levels and shorter overall survival was noted, when PDGF-B and VEGFR-3 co-expression been analyzed. Conclusion: These results suggest that the correlative expression level of PDGF-B and VEGFR-3 has strong value in the prognosis of HCC patients following hepatectomy. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：126 / 133
页数：8
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