Avapritinib reduced cutaneous symptoms and mast cell (MC) burden in patients (pts) with indolent systemic mastocytosis (ISM) in the PIONEER study

被引：0

作者：

Hartmann, K. ^{[1
]}

Broesby-Olsen, S. ^{[2
]}

Siebenhaar, F. ^{[3
,4
,5
,6
]}

Elberink, H. O. ^{[7
]}

Gotlib, J. ^{[8
]}

Sabato, V ^{[9
,10
]}

Castells, M. ^{[11
]}

Deininger, M. W. ^{[12
]}

Heaney, M. L. ^{[13
]}

George, T., I ^{[11
,12
]}

Radia, D. H. ^{[14
]}

Triggiani, M. ^{[15
]}

Van Daele, P. ^{[16
]}

Deangelo, D. J. ^{[17
]}

Schmidt-Kittler, O. ^{[18
]}

Lin, H. ^{[18
]}

Morrison, A. ^{[18
]}

Mar, B. ^{[18
]}

Akin, C. ^{[19
]}

Maurer, M. ^{[3
,4
,5
,6
]}

机构：

[1] Univ Basel, Basel, Switzerland

[2] Odense Univ Hosp, Odense, Denmark

[3] Charite Univ Med Berlin, Berlin, Germany

[4] Free Univ Berlin, Berlin, Germany

[5] Humboldt Univ, Berlin, Germany

[6] Berlin Inst Hlth, Berlin, Germany

[7] Univ Med Ctr Groningen, Groningen, Netherlands

[8] Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA

[9] Univ Antwerp, Antwerp, Belgium

[10] Antwerp Univ Hosp, Antwerp, Belgium

[11] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[12] Univ Utah, Salt Lake City, UT USA

[13] Columbia Univ, Med Ctr, New York, NY USA

[14] Guys & St Thomass NHS Fdn Trust, London, England

[15] Univ Salerno, Salerno, Italy

[16] Erasmus MC, Rotterdam, Netherlands

[17] Dana Farber Canc Inst, Boston, MA 02115 USA

[18] Blueprint Med Corp, Cambridge, MA USA

[19] Univ Michigan, Ann Arbor, MI 48109 USA

来源：

ALLERGY | 2020年 / 75卷

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

1832

引用

页码：111 / 111

页数：1

共 33 条

[1] Changes in mast cell (MC) numbers and phenotype in patients (pts) with indolent systemic mastocytosis (ISM) treated with avapritinib.
George, Tracy
Broesby-Olsen, Sigurd
Wada, David
Florell, Scott
Hartman, Karin
Siebenhaar, Frank
Akin, Cem
Newberry, Kate
Shi, Hongliang
Roche, Maria
Maurer, Marcus
Elberink, Hanneke Oude
CANCER RESEARCH, 2021, 81 (13)
[2] Avapritinib Improved Symptoms and Quality of Life in Patients With Indolent Systemic Mastocytosis in the PIONEER Study
Akin, Cem
Siebenhaar, Frank
Gotlib, Jason
Castells, Mariana
Barete, Stephane
Alvarez-Twose, Ivan
Livideanu, Cristina Bulai
Sabato, Vito
Van Daele, Paul
Pongdee, Thanai
Ward, Brant
Vadas, Peter
Bose, Prithviraj
Vachhani, Pankit
Triggiani, Massimo
Bonadonna, Patrizia
Hartmann, Karin
Oh, Stephen
Guilarte, Mar
Kuykendall, Andrew
Yi, Cecilia Arana
Ogbogu, Princess
Broesby-Olsen, Sigurd
Gaudy, Caroline
Giannetti, Matthew
Lin, Hui-Min
Scherber, Robyn
Roche, Maria
Maurer, Marcus
Elberink, Hanneke
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : AB50 - AB50
[3] AVAPRITINIB BENEFIT IN PATIENTS WITH MODERATE SYMPTOMS OF INDOLENT SYSTEMIC MASTOCYTOSIS: SUBGROUP ANALYSIS FROM PIONEER
Castells, M.
Maurer, M.
Hartmann, K.
Pongdee, T.
Ogbogu, P.
George, T.
Lampson, B.
Akin, C.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2024, 133 (06) : S83 - S83
[4] Efficacy and Safety of Avapritinib in Indolent Systemic Mastocytosis (ISM): Results from the Double Blinded Placebo-Controlled PIONEER Study
Castells, Mariana
Gotlib, Jason
Elberink, Hanneke Oude
Siebenhaar, Frank
Hartmann, Karin
Broesby-Olsen, Sigurd
George, Tracy
Panse, Jens
Alvarez-Twose, Ivan
Radia, Deepti
Tashi, Tsewang
Livideanu, Cristina Bulai
Sabato, Vito
Van Daele, Paul
Cerquozzi, Sonia
Dybedal, Ingunn
Reiter, Andreas
Pongdee, Thanai
Barete, Stephane
Schwartz, Lawrence
Bose, Prithviraj
Triggiani, Massimo
Shomali, William
Giannetti, Matthew
Bidollari, Ilda
Lin, Hui-Min
Scherber, Robyn
Roche, Maria
Akin, Cem
Maurer, Marcus
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : AB204 - AB204
[5] Efficacy and Safety of Avapritinib in Indolent Systemic Mastocytosis (ISM): Results From the Double Blinded Placebo-Controlled PIONEER Study
Castells, M.
Gotlib, J.
Elberink, H. Oude
Siebenhaar, F.
Hartmann, K.
Panse, J.
Reiter, A.
Roche, M.
Akin, C.
Maurer, M.
ALLERGOLOGIE, 2023, 46 (08) : 537 - 537
[6] Avapritinib Decreased Symptom Burden in Patients With Indolent Systemic Mastocytosis in the Registrational Double-Blind, Placebo-Controlled PIONEER Study
Giannetti, Matthew
Akin, Cem
Livideanu, Cristina Bulai
Sabato, Vito
Van Daele, Paul
Pongdee, Thanai
Barete, Stephane
Vadas, Peter
Maurer, Marcus
Siebenhaar, Frank
Triggiani, Massimo
Bonadonna, Patrizia
Hartmann, Karin
Guilarte, Mar
Ogbogu, Princess
Gaudy, Caroline
Bidollari, Ilda
Green, Teresa
Lin, Hui-Min
Roche, Maria
Sullivan, Erin
Castells, Mariana
Elberink, Hanneke Oude
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 153 (02) : AB254 - AB254
[7] AVAPRITINIB IMPROVED GASTROINTESTINAL SYMPTOMS IN PATIENTS WITH INDOLENT SYSTEMIC MASTOCYTOSIS: REGISTRATIONAL DOUBLE-BLIND, PLACEBO-CONTROLLED PIONEER STUDY
Ogbogu, P.
Livideanu, C. Bulai
Van Daele, P.
Pongdee, T.
Barete, S.
Vadas, P.
Shaheen, D.
Sabato, V.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2023, 131 (05) : S81 - S81
[8] Results from PIONEER: A randomized, double-blind, placebo-controlled, phase 2 study of avapritinib in patients with indolent systemic mastocytosis (ISM)
Maurer, M.
Elberink, H. O.
Gotlib, J.
Sabato, V.
Hartmann, K.
Broesby-Olsen, S.
Castells, M.
Deininger, M. W.
Heaney, M. L.
George, T. I.
Siebenhaar, F.
Radia, D.
Triggiani, M.
van Daele, P.
Deangelo, D. J.
Schmidt-Kittler, O.
Lin, H. -M.
Morrison, A.
Mar, B.
Akin, C.
ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (SUPPL 4) : 77 - 77
[9] Reductions in Indolent Systemic Mastocytosis Biomarker Burden With Avapritinib in the Registrational, Double-Blind, Placebo-Controlled PIONEER Trial
Gotlib, Jason
Castells, Mariana
Elberink, Hanneke Oude
Siebenhaar, Frank
Hartmann, Karin
Broesby-Olsen, Sigurd
George, Tracy I.
Panse, Jens
Alvarez-Twose, Ivan
Radia, Deepti H.
Tashi, Tsewang
Livideanu, Cristina Bulai
Sabato, Vito
Van Daele, Paul
Cerquozzi, Sonia
Dybedal, Ingunn
Reiter, Andreas
Ustun, Celalettin
Schafhausen, Philippe
Bose, Prithviraj
DeAngelo, Daniel J.
Rein, Lindsay
Vachhani, Pankit
Triggiani, Massimo
Rafferty, Mark
Butt, Nauman M.
Oh, Stephen T.
Wortmann, Friederike
Ungerstedt, Johanna
Taparia, Minakshi
Kuykendall, Andrew T.
Yi, Cecilia Arana
Mattsson, Mattias
Shomali, William
Giannetti, Matthew P.
Bidollari, Ilda
Lin, Hui-Min
Scherber, Robyn
Roche, Maria
Akin, Cem
Maurer, Marcus
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S398 - S399
[10] Results from PIONEER: a randomized, double-blind, placebo-controlled, phase 2 study of avapritinib in patients with indolent systemic mastocytosis
Radia, Deepti H.
Sabato, Vito
Castells, Mariana
Akin, Cem
Elberink, Hanneke Oude
Tashi, Tsewang
George, Tracy I.
Roche, Maria
DeAngelo, Daniel J.
Gotlib, Jason
BRITISH JOURNAL OF HAEMATOLOGY, 2021, 193 : 8 - 9

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