Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates

被引：15
|
作者：
Kamal, A [1 ]
Reddy, DR [1 ]
Reddy, PSMM [1 ]
Rajendar [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 05期
关键词：
pyrrolobenzodiazepine; hydroxyazepane; DNA-binding ability;
D O I：
10.1016/j.bmcl.2005.11.090
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of pyrrolobenzodiazepine-azepane conjugates linked through different alkane spacers have been prepared and their DNA thermal denaturation studies have been carried out. One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 degrees C after incubation for 36 h at 37 degrees C. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1160 / 1163
页数：4
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