Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits

被引：15

作者：

Wu, Xingxing ^{[1
]}

Chen, Yulin ^{[1
]}

Gui, Shuangying ^{[1
,2
]}

Wu, Xiaoqing ^{[1
]}

Chen, Lei ^{[1
]}

Cao, Yingji ^{[1
]}

Yin, Dengke ^{[1
]}

Ma, Ping ^{[3
]}

机构：

[1] Anhui Univ Chinese Med, Dept Pharm, Hefei, Peoples R China

[2] Anhui Engn Res Ctr Chinese Med Preparat, Hefei, Peoples R China

[3] Hospira Inc, Global Pharmaceut Res & Dev, Mcpherson, KS USA

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2016年 / 21卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Dissolving microneedle; sinomenine hydrochloride; transdermal drug delivery; TRANSDERMAL DRUG-DELIVERY; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; IN-VITRO; TRANSCUTANEOUS IMMUNIZATION; PERCUTANEOUS DELIVERY; POLYMER MICRONEEDLES; MALTOSE MICRONEEDLES; VACCINE DELIVERY; RAT SKIN;

D O I：

10.3109/10837450.2015.1055766

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.

引用

页码：787 / 793

页数：7

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