Clostridium difficile:: still surprising after 30 years
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作者:
Martirosian, Gayane
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Uniwersytetu Med, Katedra & Zaklad Mikrobiol Lekarskiej Slaskiego, PL-40752 Katowice, Poland
Uniwersytetu Med Warszawie, Katedra & Zaklad Histol & Embriol, Warsaw, PolandUniwersytetu Med, Katedra & Zaklad Mikrobiol Lekarskiej Slaskiego, PL-40752 Katowice, Poland
Martirosian, Gayane
[1
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[1] Uniwersytetu Med, Katedra & Zaklad Mikrobiol Lekarskiej Slaskiego, PL-40752 Katowice, Poland
[2] Uniwersytetu Med Warszawie, Katedra & Zaklad Histol & Embriol, Warsaw, Poland
The first paper that established the etiological role of Clostridium difficile in pseudomembranous colitis was published in the New England Journal of Medicine in March 1978. Since 2000, the epidemiology and clinical severity of C. difficile-associated diseases changed dramatically, especially in North America and Europe, with the emergence of a new hypervirulent strain NAP1/027. The epidemiology, pathomechanisms, clinical manifestations and treatment problems of infections caused by this hypervirulent strain of C. difficile are analyzed in this paper according to recently published data.
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Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kim, Ho Seung
Kang, Jae Hyun
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Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kang, Jae Hyun
Kim, Han-gil
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Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kim, Han-gil
Kim, Young Hun
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Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Kim, Young Hun
Bae, Hyeonwoo
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Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
Bae, Hyeonwoo
Kim, Nam Kyu
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Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South KoreaYonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Chem, Cambridge, MA 02139 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
Brignole, Edward J.
Ando, Nozomi
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MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Chem, Cambridge, MA 02139 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
Ando, Nozomi
Zimanyi, Christina M.
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MIT, Dept Chem, Cambridge, MA 02139 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
Zimanyi, Christina M.
Drennan, Catherine L.
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MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Chem, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA