ONE-POT SYNTHESIS OF 1H-BENZIMIDAZOLE DERIVATIVES USING THIAMINE HYDROCHLORIDE AS A REUSABLE ORGANOCATALYST

被引：38
|
作者：
Lei, Min
Ma, Lei [1 ,2 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 20期
基金：
中国国家自然科学基金;
关键词：
Aldehyde; 1H-benzimidazole; green chemistry; o-phenylenediamine; thiamine hydrochloride (VB1); BENZIMIDAZOLE DERIVATIVES; EFFICIENT SYNTHESIS; 2-SUBSTITUTED BENZIMIDAZOLES; CATALYST; 2-ARYL-1-ARYLMETHYL-1H-BENZIMIDAZOLES; ALDEHYDES; CONDENSATION; DESIGN; SYSTEM; WATER;
D O I：
10.1080/00397911.2011.573610
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using thiamine hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst.
引用
收藏
页码：2981 / 2993
页数：13
相关论文
共 50 条
  • [31] One-pot synthesis of 2-(1-alkyl/aralkyl-1H-benzimidazole-2-yl)-quinoxaline derivatives using molecular iodine
    Dubey, P. K.
    Reddy, P. V. V. Prasada
    Srinivas, K.
    SYNTHETIC COMMUNICATIONS, 2008, 38 (04) : 613 - 618
  • [32] 5-Sulphosalicylic Acid: An Expeditious Organocatalyst for One-pot Synthesis of Indenopyrazolones and its Derivatives
    Kushwaha, Smriti
    Singh, Swastika
    Baranwal, Jyoti
    Jyoti, Archana
    CURRENT ORGANOCATALYSIS, 2024, 11 (03) : 175 - 184
  • [33] Selective one-pot synthetic method for imidazole and benzimidazole derivatives
    Jiang, ZL
    Xiao, R
    Su, XY
    Yan, JM
    Xie, RG
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2003, 24 (01): : 64 - 67
  • [34] Effective one-pot synthesis of H type 1 and 2 trisaccharide derivatives using glycal epoxide
    Tanaka, H
    Matoba, N
    Takahashi, T
    CHEMISTRY LETTERS, 2005, 34 (03) : 400 - 401
  • [35] A Convenient One-Pot Synthesis of Novel Benzimidazole-Thiazinone Derivatives and Their Antimicrobial Activity
    Samreen, Sabahat
    Ali, Asghar
    Ahmedi, Saiema
    Raghib, Mohammad
    Haque, Anzarul
    Manzoor, Nikhat
    Hussain, Afzal
    Abid, Mohammad
    Inam, Afreen
    ANTIBIOTICS-BASEL, 2024, 13 (12):
  • [36] Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
    Kopanska, K
    Najda, A
    Zebrowska, J
    Chomicz, L
    Piekarczyk, J
    Myjak, P
    Bretner, M
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (10) : 2617 - 2624
  • [37] Facile and Convenient One-Pot Process for the Synthesis of Spirooxindole Derivatives in High Optical Purity Using (-)-(S)-Brevicolline as an Organocatalyst
    Macaev, Fliur
    Sucman, Natalia
    Shepeli, Felix
    Zveaghintseva, Marina
    Pogrebnoi, Vsevolod
    SYMMETRY-BASEL, 2011, 3 (02): : 165 - 170
  • [38] Thiamine Hydrochloride: A Highly Efficient Organo-Catalyst for the One-Pot Synthesis of 2, 4, 5-Triaryl Imidazole Derivatives
    Phatangare, Kishor B.
    Gadkari, Yatin U.
    Lomte, Savita B.
    Salim, Simren S.
    Telvekar, Vikas N.
    LETTERS IN ORGANIC CHEMISTRY, 2025, 22 (01) : 2 - 7
  • [39] One-pot synthesis of imidazopyridine derivatives
    Parenty, Alexis D. C.
    Cronin, Leroy
    SYNTHESIS-STUTTGART, 2008, (09): : 1479 - 1485
  • [40] An Efficient One-Pot Multicomponent Synthesis of Dihydropyridines by using Succinic Acid as Mild Organocatalyst
    Patil, Suresh
    Pawar, P. B.
    Jadhav, S. D.
    Deshmukh, M. B.
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (17) : 9442 - 9446
12345