ONE-POT SYNTHESIS OF 1H-BENZIMIDAZOLE DERIVATIVES USING THIAMINE HYDROCHLORIDE AS A REUSABLE ORGANOCATALYST

被引：38

作者：

Lei, Min

Ma, Lei ^{[1
,2
]}

Hu, Lihong ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Aldehyde; 1H-benzimidazole; green chemistry; o-phenylenediamine; thiamine hydrochloride (VB1); BENZIMIDAZOLE DERIVATIVES; EFFICIENT SYNTHESIS; 2-SUBSTITUTED BENZIMIDAZOLES; CATALYST; 2-ARYL-1-ARYLMETHYL-1H-BENZIMIDAZOLES; ALDEHYDES; CONDENSATION; DESIGN; SYSTEM; WATER;

D O I：

10.1080/00397911.2011.573610

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using thiamine hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst.

引用

页码：2981 / 2993

页数：13

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