Current and future antenatal management of isolated congenital diaphragmatic hernia

被引：31

作者：

Russo, Francesca Maria ^{[1
,2
]}

De Coppi, Paolo ^{[1
,2
,3
,4
,5
]}

Allegaert, Karel ^{[1
,2
,6
]}

Toelen, Jaan ^{[1
,2
]}

van der Veeken, Lennart ^{[1
,2
]}

Attilakos, George ^{[3
,4
]}

Eastwood, Mary Patrice ^{[1
,2
,3
,4
]}

David, Anna Louise ^{[3
,4
]}

Deprest, Jan ^{[1
,2
,3
,4
]}

机构：

[1] Katholieke Univ Leuven, Acad Dept Dev & Regenerat, Clin Specialties Res Grp, Biomed Sci, Leuven, Belgium

[2] Katholieke Univ Leuven, Clin Dept Obstet & Gynaecol, Leuven, Belgium

[3] UCL, Inst Womens Hlth, London, England

[4] UCL, Inst Child Hlth, London, England

[5] Great Ormond St Hosp Sick Children, London, England

[6] Erasmus MC, Intens Care Unit Children, Sophia Hosp Children, Rotterdam, Netherlands

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2017年 / 22卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国惠康基金;

关键词：

Congenital diaphragmatic hernia; Prenatal therapy; Pulmonary hypoplasia; Pulmonary hypertension; Sildenafil; ENDOSCOPIC TRACHEAL OCCLUSION; PULMONARY ARTERIAL-HYPERTENSION; EXTRACORPOREAL MEMBRANE-OXYGENATION; RANDOMIZED-CONTROLLED-TRIAL; SILDENAFIL CITRATE THERAPY; AND/OR SILDENAFIL; PERFUSION MODEL; RABBIT MODEL; NITRIC-OXIDE; DOUBLE-BLIND;

D O I：

10.1016/j.siny.2017.11.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital diaphragmatic hernia is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome may be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. However, prenatal modulation of lung development remains experimental. Fetoscopic endoluminal tracheal occlusion triggers lung growth and is currently being evaluated in a global clinical trial. Prenatal transplacental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：383 / 390

页数：8

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