Observational study on Swedish plaque psoriasis patients receiving narrowband-UVB treatment show decreased S100A8/A9 protein and gene expression levels in lesional psoriasis skin but no effect on S100A8/A9 protein levels in serum

被引：13
|
作者：
Duvetorp, Albert [1 ,2 ]
Soderman, Jan [2 ,3 ]
Assarsson, Malin [4 ]
Skarstedt, Marita [3 ]
Svensson, Ake [1 ]
Seifert, Oliver [2 ,4 ]
机构：
[1] Skane Univ Hosp, Dept Dermatol & Venereol, Div Endocrinol Skin Reprod Hlth & Ophthalmol, Malmo, Sweden
[2] Linkoping Univ, Dept Clin & Expt Med, Fac Med & Hlth Sci, Linkoping, Sweden
[3] Ryhov Cty Hosp, Div Med Diagnost, Lab Med, Jonkoping, Sweden
[4] Ryhov Cty Hosp, Div Med Hlth, Dept Dermatol & Venereol, Jonkoping, Sweden
来源：
PLOS ONE | 2019年 / 14卷 / 03期
关键词：
S100; PROTEINS; CALPROTECTIN S100A8/S100A9; CARDIOVASCULAR-DISEASE; DIFFERENTIATION; KERATINOCYTES; PHOTOTHERAPY; INFLAMMATION; ULTRAVIOLET; COMPLEX; PCR;
D O I：
10.1371/journal.pone.0213344
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
S100A8 and S100A9 proteins are highly upregulated in patients with psoriasis and have been proposed as potential biomarkers for psoriasis. The present study was designed to analyze the effect of narrowband ultraviolet B therapy on these proteins. S100A8, S100A9 gene expression and S100A8/A9 heterocomplex protein levels were analyzed in lesional and non-lesional skin before and after narrowband-UVB treatment in patients with chronic plaque type psoriasis. In addition, disease severity was measured by psoriasis area and severity index (PASI) and serum protein levels of S100A8/A9 were repeatedly analyzed. Narrowband-UVB treatment significantly reduced S100A8, S100A9 gene expression and S100A8/A9 protein levels in lesional skin while serum levels showed no significant change. No correlation between PASI and serum S100A8/A9 protein levels was found. These results implicate a role of S100A8/A9 in the anti-inflammatory effect of narrowband-UVB. Serum S100A8/A9 levels do not respond to treatment suggesting that serum S100A8/A9 does not originate from psoriasis skin keratinocytes. Serum S100A8/A9 levels do not correlate with PASI questioning serum S100A8/A9 as a biomarker for psoriasis skin activity.
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页数：16
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