Synthesis, conformational analysis and antitumor testing of 5-(Z)-arylidene-4-imidazolidinone derivatives

被引：33
|
作者：
Khodair, AI
El-Subbagh, HI
Al-Obaid, AM
机构：
[1] Tanta Univ, Fac Educ, Dept Chem, Kafr El Sheikh Branch, Tanta, Egypt
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1998年 / 140卷
关键词：
2-thioxo-4-imidazolidinone; 5-(Z)-arylidene-4-imidazolidinone derivatives; conformational analysis and antitumoral activity;
D O I：
10.1080/10426509808035741
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of 5-(Z)-arylidene-2-amino-4-imidazolidinones 16-34, 5-(Z)-arylidene-2-(2-carboxyphenylamino)-4-imidazolidinones 35-41, 5-(Z)-arylidene-3-aminomethyl-2-thioxo-4-imidazolidinones 42-55 and 5-(Z)-arylidene-3-aminomethyl-2-methylmercapto-4-imidazolidinones 56-67 have been synthesized via two different routes. Conformational analysis and antitumor activities have been studied. The antitumor activity of these compounds showed broad spectrum of activity against a wide range of different human cell lines of nine tumor subpanels causing both cytostatic and cytotoxic potency.
引用
收藏
页码：159 / 181
页数：23
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