Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence

被引：0
|
作者：
Gomes Gouvea, Maria da Penha [1 ]
Moulaz, Isac Ribeiro [2 ]
Gouveia, Thayna Martins [2 ]
Monlevade Lanca, Karen Evelin [2 ]
de Paula Lacerda, Barbara Sthefany [2 ]
Thompson, Beatriz Paoli [2 ]
Polese, Jessica [3 ]
de Lima, Marina Deorce [2 ]
Ribeiro-Rodrigues, Rodrigo [4 ,5 ]
Mill, Jose Geraldo [6 ]
Valim, Valeria [7 ]
机构：
[1] Univ Fed Espirito Santo, Hosp Univ Cassiano Antonio Moraes, Vitoria, ES, Brazil
[2] Univ Fed Espirito Santo, Ctr Ciencias Saude, Vitoria, ES, Brazil
[3] Univ Fed Espirito Santo, Ctr Ciencias Saude, Dept Pneumol, Vitoria, ES, Brazil
[4] Dept Saude Estado Espirito Santo, Lab Saude Publ Estado Espirito Santo, Vitoria, ES, Brazil
[5] Univ Fed Espirito Santo, Ctr Ciencias Saude, Ctr Doencas Infecciosas, Vitoria, ES, Brazil
[6] Univ Fed Espirito Santo, Ctr Ciencias Saude, Dept Ciencias Fisiol, Vitoria, ES, Brazil
[7] Univ Fed Espirito Santo, Hosp Univ Cassiano Antonio Moraes, Div Reumatol, Vitoria, ES, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2022年 / 55卷
关键词：
COVID-19; SARS-CoV-2; Recurrence; Humoral Reactivity;
D O I：
10.1590/0037-8682-0106-2022
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Background: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence. Methods: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N. Results: Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms. Conclusions: Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence.
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页数：5
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