Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions

被引：28

作者：

Zhang, Yiyin ^{[1
,2
,3
,4
]}

Yang, Chao ^{[1
,2
,3
,4
]}

Cheng, He ^{[1
,2
,3
,4
]}

Fan, Zhiyao ^{[1
,2
,3
,4
]}

Huang, Qiuyi ^{[1
,2
,3
,4
]}

Lu, Yu ^{[1
,2
,3
,4
]}

Fan, Kun ^{[1
,2
,3
,4
]}

Luo, Guopei ^{[1
,2
,3
,4
]}

Jin, Kaizhou ^{[1
,2
,3
,4
]}

Wang, Zhengshi ^{[1
,2
,3
,4
]}

Liu, Chen ^{[1
,2
,3
,4
]}

Yu, Xianjun ^{[1
,2
,3
,4
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Pancreat Surg, 270 DongAn Rd, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, 270 DongAn Rd, Shanghai 200032, Peoples R China

[3] Shanghai Pancreat Canc Inst, 270 DongAn Rd, Shanghai 200032, Peoples R China

[4] Fudan Univ, Pancreat Canc Inst, 270 DongAn Rd, Shanghai 200032, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2018年 / 11卷

基金：

中国国家自然科学基金;

关键词：

Pancreatic ductal adenocarcinoma; Novel regimens; Biomarkers; Combination therapies; GEMCITABINE PLUS PLACEBO; PHASE-II TRIAL; ALGENPANTUCEL-L IMMUNOTHERAPY; STANDARD ADJUVANT THERAPY; DOUBLE-BLIND; MESENCHYMAL TRANSITION; E-CADHERIN; RESECTABLE ADENOCARCINOMA; PREOPERATIVE GEMCITABINE; IONIZING-RADIATION;

D O I：

10.1186/s13045-017-0551-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A poor prognosis of pancreatic ductal adenocarcinoma (PDAC) associated with chemoresistance has not changed for the past three decades. A multidisciplinary diagnosis followed by surgery and chemo(radiation) therapy is the main treatment approach. However, gemcitabine-and 5-fluorouracil-based therapies did not present satisfying outcomes. Novel regimens targeting pancreatic cancer cells, the tumor microenvironment, and immunosuppression are emerging. Biomarkers concerning the treatment outcome and patient selection are being discovered in preclinical or clinical studies. Combination therapies of classic chemotherapeutic drugs and novel agents or novel therapeutic combinations might bring hope to the dismal prognosis for PDAC patients.

引用

页数：17

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