Differential propensity of citrate- and polyethylene glycol-coated silver nanoparticles to bovine hemoglobin

被引：7

作者：

Zolghadri, Samaneh ^{[1
]}

Saboury, Ali Akbar ^{[2
]}

Atri, Maliheh Sadat ^{[3
]}

Moosavi-Movahedi, A. A. ^{[2
]}

机构：

[1] Islamic Azad Univ, Jahrom Branch, Dept Biol, Jahrom, Iran

[2] Univ Tehran, Inst Biochem & Biophys, Tehran 1417614411, Iran

[3] Univ Mazandaran, Fac Basic Sci, Mol & Cell Biol Dept, Babol Sar, Iran

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2015年 / 31卷 / 08期

关键词：

Citrate-coated silver nanoparticles; hemoglobin; circular dichroism; fluorescence; titration calorimetry; nanoparticle safety; ESCHERICHIA-COLI;

D O I：

10.1177/0748233713483193

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Propensity of two different silver nanoparticles (Ag-NPs) to bovine hemoglobin (BHb) was investigated by means of spectroscopic methods. We have combined spectrophotometric and calorimetric methods to show that there is no significant interaction between citrate-coated Ag-NPs and BHb at physiological pH and 20 degrees C. However, our previous results show that polyethylene glycol-coated Ag-NPs strongly bind to Hb and effect on the secondary and tertiary structures of BHb. Thus, a suitable surface coating and modification of surface charge would increase the NPs safety and reduce adverse biological responses.

引用

页码：721 / 726

页数：6

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