Tachyarrhythmias During Hospitalization for COVID-19 or Multisystem Inflammatory Syndrome in Children and Adolescents

被引：7

作者：

Dionne, Audrey ^{[1
]}

Friedman, Kevin G. ^{[1
]}

Young, Cameron C. ^{[2
]}

Newhams, Margaret M. ^{[2
]}

Kucukak, Suden ^{[2
]}

Jackson, Ashley M. ^{[3
]}

Fitzgerald, Julie C. ^{[4
]}

Smallcomb, Laura S. ^{[5
]}

Heidemann, Sabrina ^{[6
]}

McLaughlin, Gwenn E. ^{[7
]}

Irby, Katherine ^{[8
]}

Bradford, Tamara T. ^{[9
,10
]}

Horwitz, Steven M. ^{[11
]}

Loftis, Laura L. ^{[12
]}

Soma, Vijaya L. ^{[13
,14
]}

Rowan, Courtney M. ^{[15
]}

Kong, Michele ^{[16
]}

Halasa, Natasha B. ^{[17
]}

Tarquinio, Keiko M. ^{[18
]}

Schwarz, Adam J. ^{[19
]}

Hume, Janet R. ^{[20
]}

Gertz, Shira J. ^{[21
]}

Clouser, Katharine N. ^{[22
]}

Carroll, Christopher L. ^{[23
]}

Wellnitz, Kari ^{[24
]}

Cullimore, Melissa L. ^{[25
]}

Doymaz, Sule ^{[26
]}

Levy, Emily R. ^{[27
,28
]}

Typpo, Katri, V ^{[29
]}

Lansell, Amanda N. ^{[30
]}

Butler, Andrew D. ^{[31
]}

Kuebler, Joseph D. ^{[32
]}

Zambrano, Laura D. ^{[3
]}

Campbell, Angela P. ^{[3
]}

Patel, Manish M. ^{[3
]}

Randolph, Adrienne G. ^{[2
,33
,34
]}

Newburger, Jane W. ^{[1
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Cardiol, Dept Pediat, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA

[3] Ctr Dis Control & Prevent, COVID 19 Response, Atlanta, GA USA

[4] Univ Penn, Dept Anesthesiol & Crit Care, Div Crit Care, Perelman Sch Med, Philadelphia, PA USA

[5] Med Univ South Carolina, Dept Pediat, Charleston, SC USA

[6] Cent Michigan Univ, Dept Pediat, Div Pediat Crit Care Med, Detroit, MI USA

[7] Univ Miami, Dept Pediat, Div Pediat Crit Care Med, Miller Sch Med, Miami, FL USA

[8] Arkansas Childrens Hosp, Dept Pediat, Sect Pediat Crit Care, Little Rock, AR USA

[9] Louisiana State Univ, Dept Pediat, Div Cardiol, Hlth Sci Ctr, New Orleans, LA USA

[10] Childrens Hosp New Orleans, New Orleans, LA USA

[11] Rutgers Robert Wood Johnson Med Sch, Dept Pediat, Div Pediat Crit Care Med, New Brunswick, NJ USA

[12] Texas Childrens Hosp, Dept Pediat, Sect Crit Care Med, Houston, TX USA

[13] NYU, Dept Pediat, Div Infect Dis, Grossman Sch Med, New York, NY USA

[14] Hassenfeld Childrens Hosp, New York, NY USA

[15] Indiana Univ Sch Med, Riley Hosp Children, Dept Pediat, Div Pediat Crit Care Med, Indianapolis, IN USA

[16] Univ Alabama Birmingham, Dept Pediat, Div Pediat Crit Care Med, Birmingham, AL USA

[17] Vanderbilt Univ, Dept Pediat, Div Pediat Infect Dis, Med Ctr, Nashville, TN USA

[18] Emory Univ, Dept Pediat, Div Crit Care Med, Childrens Healthcare Atlanta,Sch Med, Atlanta, GA USA

[19] CHOC Childrens Hosp, Div Crit Care Med, Orange, CA USA

[20] Univ Minnesota, Div Pediat Crit Care, Masonic Childrens Hosp, Minneapolis, MN USA

[21] Cooperman Bamabas Med Ctr, Dept Pediat, Div Pediat Crit Care, Livingston, NJ USA

[22] Hackensack Meridian Sch Med, Dept Pediat, Hackensack, NJ USA

[23] Connecticut Childrens Med Ctr, Div Crit Care, Hartford, CT USA

[24] Univ Iowa, Stead Family Dept Pediat, Div Pediat Crit Care, Carver Coll Med, Iowa City, IA USA

[25] Childrens Hosp & Med Ctr, Dept Pediat, Div Pediat Crit Care, Omaha, NE USA

[26] SUNY Downstate Hlth Sci Univ, Dept Pediat, Div Pediat Crit Care, Brooklyn, NY USA

[27] Mayo Clin, Div Pediat Infect Dis, Dept Pediat & Adolescent Med, Rochester, MN USA

[28] Mayo Clin, Div Pediat Crit Care Med, Dept Pediat & Adolescent Med, Rochester, MN USA

[29] Univ Arizona, Dept Pediat, Div Pediat Crit Care, Tucson, AZ USA

[30] Rainbow Babies & Childrens Hosp, Div Pediat Hosp Med, Cleveland, OH USA

[31] St Christophers Hosp Children, Div Pediat Crit Care, Philadelphia, PA USA

[32] Univ Rochester, Golisano Childrens Hosp, Dept Pediat, Div Pediat Crit Care, Rochester, NY USA

[33] Harvard Med Sch, Dept Anaesthesia, Boston, MA 02115 USA

[34] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2022年 / 11卷 / 20期

关键词：

COVID-19; multisystem inflammatory syndrome in children (MIS-C); tachyarrhythmia; SCIENTIFIC STATEMENT; ARRHYTHMIAS; MANAGEMENT; DIAGNOSIS;

D O I：

10.1161/JAHA.122.025915

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Cardiac complications related to COVID-19 in children and adolescents include ventricular dysfunction, myocarditis, coronary artery aneurysm, and bradyarrhythmias, but tachyarrhythmias are less understood. The goal of this study was to evaluate the frequency, characteristics, and outcomes of children and adolescents experiencing tachyarrhythmias while hospitalized for acute severe COVID-19 or multisystem inflammatory syndrome in children. Methods and Results This study involved a case series of 63 patients with tachyarrhythmias reported in a public health surveillance registry of patients aged <21 years hospitalized from March 15, 2020, to December 31, 2021, at 63 US hospitals. Patients with tachyarrhythmias were compared with patients with severe COVID-19-related complications without tachyarrhythmias. Tachyarrhythmias were reported in 22 of 1257 patients (1.8%) with acute COVID-19 and 41 of 2343 (1.7%) patients with multisystem inflammatory syndrome in children. They included supraventricular tachycardia in 28 (44%), accelerated junctional rhythm in 9 (14%), and ventricular tachycardia in 38 (60%); >1 type was reported in 12 (19%). Registry patients with versus without tachyarrhythmia were older (median age, 15.4 [range, 10.4-17.4] versus 10.0 [range, 5.4-14.8] years) and had higher illness severity on hospital admission. Intervention for treatment of tachyarrhythmia was required in 37 (59%) patients and included antiarrhythmic medication (n=31, 49%), electrical cardioversion (n=11, 17%), cardiopulmonary resuscitation (n=8, 13%), and extracorporeal membrane oxygenation (n=9, 14%). Patients with tachyarrhythmias had longer hospital length of stay than those who did not, and 9 (14%) versus 77 (2%) died. Conclusions Tachyarrhythmias were a rare complication of acute severe COVID-19 and multisystem inflammatory syndrome in children and adolescents and were associated with worse clinical outcomes, highlighting the importance of close monitoring, aggressive treatment, and postdischarge care.

引用

页数：31

共 50 条

[41] Multisystem inflammatory syndrome in children related to COVID-19: a systematic review
Hoste, Levi
Van Paemel, Ruben
Haerynck, Filomeen
EUROPEAN JOURNAL OF PEDIATRICS, 2021, 180 (07) : 2019 - 2034
[42] Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Sacco, Keith
Castagnoli, Riccardo
Vakkilainen, Svetlana
Liu, Can
Delmonte, Ottavia M.
Oguz, Cihan
Kaplan, Ian M.
Alehashemi, Sara
Burbelo, Peter D.
Bhuyan, Farzana
de Jesus, Adriana A.
Dobbs, Kerry
Rosen, Lindsey B.
Cheng, Aristine
Shaw, Elana
Vakkilainen, Mikko S.
Pala, Francesca
Lack, Justin
Zhang, Yu
Fink, Danielle L.
Oikonomou, Vasileios
Snow, Andrew L.
Dalgard, Clifton L.
Chen, Jinguo
Sellers, Brian A.
Sanchez, Gina A. Montealegre
Barron, Karyl
Rey-Jurado, Emma
Vial, Cecilia
Poli, Maria Cecilia
Licari, Amelia
Montagna, Daniela
Marseglia, Gian Luigi
Licciardi, Francesco
Ramenghi, Ugo
Discepolo, Valentina
Lo Vecchio, Andrea
Guarino, Alfredo
Eisenstein, Eli M.
Imberti, Luisa
Sottini, Alessandra
Biondi, Andrea
Mato, Sayonara
Gerstbacher, Dana
Truong, Meng
Stack, Michael A.
Magliocco, Mary
Bosticardo, Marita
Kawai, Tomoki
Danielson, Jeffrey J.
NATURE MEDICINE, 2022, 28 (05) : 1050 - +
[43] Update on the treatment of multisystem inflammatory syndrome in children associated with COVID-19
Long, Fangyuan
Zhu, Shiheng
Wang, Zeguang
Zhang, Shungeng
He, Jinlong
Ge, Xinbin
Ning, Jun
FUTURE VIROLOGY, 2023, 18 (01) : 63 - 74
[44] Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19
Blondiaux, Eleonore
Parisot, Pauline
Redheuil, Alban
Tzaroukian, Lucile
Levy, Yael
Sileo, Chiara
Schnuriger, Aurelie
Lorrot, Mathie
Guedj, Romain
le Pointe, Hubert Ducou
RADIOLOGY, 2020, 297 (03) : E283 - E288
[45] Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19
Ciftci, Ergin
Arga, Gul
Taskin, Esra Cakmak
Konca, Hatice Kubra
Ozdemir, Halil
JOURNAL OF PEDIATRIC INFECTION, 2020, 14 (04): : 261 - 261
[46] MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN: A NEW CHALLENGE IN THE COVID-19 PANDEMIC
Ferguson, B.
Kala, M. D.
Hodge, D. G.
Harrison, V. A.
JOURNAL OF INVESTIGATIVE MEDICINE, 2021, 69 (02) : 486 - 487
[47] Multisystem Inflammatory Syndrome in Children Associated with COVID-19: An Interim Review
Behera, Jyoti R.
Jain, Mukesh K.
Sahu, Sanjay K.
Patnaik, Sibabratta
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, 2021, 16 (04) : 137 - 147
[48] Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children
Boribong, Brittany P.
LaSalle, Thomas J.
Bartsch, Yannic C.
Ellett, Felix
Loiselle, Maggie E.
Davis, Jameson P.
Gonye, Anna L. K.
Sykes, David B.
Hajizadeh, Soroush
Kreuzer, Johannes
Pillai, Shiv
Haas, Wilhelm
Edlow, Andrea G.
Fasano, Alessio
Alter, Galit
Irimia, Daniel
Sade-Feldman, Moshe
Yonker, Lael M.
CELL REPORTS MEDICINE, 2022, 3 (12)
[49] Radiological findings of multisystem inflammatory syndrome in children associated with COVID-19
Kalin, Sevinc
Sozeri, Betul
BRITISH JOURNAL OF RADIOLOGY, 2022, 95 (1136):
[50] Imaging findings of multisystem inflammatory syndrome in children associated with COVID-19
Caro-Dominguez, Pablo
Navallas, Maria
Riaza-Martin, Lucia
Ghadimi Mahani, Maryam
Ugas Charcape, Carlos F.
Valverde, Israel
D'Arco, Felice
Toso, Seema
Shelmerdine, Susan Cheng
van Schuppen, Joost
Secinaro, Aurelio
Grafe, Daniel
Camacho, Marisol
Neth, Olaf
Goo, Hyun Woo
Kellenberger, Christian J.
PEDIATRIC RADIOLOGY, 2021, 51 (09) : 1608 - 1620

← 1 2 3 4 5 →