Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation

被引：34
|
作者：
Chen, Jiaxin [1 ,2 ]
Liu, Shuiping [1 ,2 ]
Hu, Xiaotong [1 ,2 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Biomed Res Ctr, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Key Lab Biotherapy Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
来源：
CELL DEATH DISCOVERY | 2018年 / 4卷
基金：
中国国家自然科学基金;
关键词：
COMPETING ENDOGENOUS RNA; COLORECTAL-CARCINOMA PROGRESSION; PROMOTES TUMOR-GROWTH; GASTRIC-CANCER; POOR-PROGNOSIS; HEPATOCELLULAR-CARCINOMA; DECREASED EXPRESSION; MALAT1; PROMOTES; DOWN-REGULATION; UP-REGULATION;
D O I：
10.1038/s41420-018-0051-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Studies of long non-coding RNAs (lncRNAs) have been prevalent in the field of non-coding RNA regulation in recent years. LncRNAs exert crucial effects on malignant cell processes in the gastrointestinal system, including proliferation. Aberrant lncRNA expression, through both oncogenes and tumor suppressor genes, is instrumental to tumor cell proliferation. Here, we summarize the different molecular mechanisms and relevant signaling pathways through which multifarious lncRNAs regulate cell proliferation and we show that lncRNAs are potential biomarkers for gastrointestinal cancers.
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页数：11
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