Asymmetric Michael Reaction Catalyzed by Proline Lithium Salt: Efficient Synthesis of L-Proline and Isoindoloisoquinolinone Derivatives

被引：47
|
作者：
Xu, Kun [1 ,2 ]
Zhang, Sheng [1 ,2 ]
Hu, Yanbin [1 ,2 ]
Zha, Zhenggen [1 ,2 ]
Wang, Zhiyong [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 11期
基金：
中国国家自然科学基金;
关键词：
asymmetric catalysis; enamines; lithium; Michael addition; proline; ENANTIOSELECTIVE CONJUGATE ADDITION; DIRECT ALDOL REACTION; AMINO-ACID; UNMODIFIED ALDEHYDES; ENAMINE CATALYSIS; KETONES; ORGANOCATALYSTS; COMPLEX; FUNCTIONALIZATION; MALONATE;
D O I：
10.1002/chem.201202409
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lithium makes it possible: The enantioselective Michael addition of aldehydes to nitroalkenes was catalyzed by the readily available proline lithium salt. Remarkably, the asymmetric Michael reaction was scaled up to 50 mmol with 23:1 d.r. and 90 % ee. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3573 / 3578
页数：6
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