Synthesis and properties of spiro nucleosides containing the barbituric acid moiety

被引：68
|
作者：
Renard, A [1 ]
Lhomme, J [1 ]
Kotera, M [1 ]
机构：
[1] Univ Grenoble 1, LEDSS, CNRS, F-38041 Grenoble 9, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 04期
关键词：
D O I：
10.1021/jo016194y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The two chiral spiro nucleosides 4 and 5 containing the barbituric acid moiety were efficiently synthesized from optically pure precursors, and their properties were studied. The carbocyclic nucleoside 5 is considerably more stable against ring opening than the deoxyribosyl derivative 4. Both compounds present enhanced hydrogen bonding capacity with diacetyladenosine.
引用
收藏
页码：1302 / 1307
页数：6
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