Developing long-acting growth hormone formulations

被引：27

作者：

Cawley, Pippa ^{[1
]}

Wilkinson, Ian ^{[1
]}

Ross, Richard J. ^{[1
]}

机构：

[1] Univ Sheffield, Acad Unit Diabet Endocrinol & Reprod, Sheffield S10 2RX, S Yorkshire, England

来源：

CLINICAL ENDOCRINOLOGY | 2013年 / 79卷 / 03期

关键词：

PREPARATION NUTROPIN DEPOT; GH PREPARATION; PHARMACODYNAMIC CHARACTERISTICS; FACTOR-I; PHARMACOKINETICS; CHILDREN; EFFICACY; LB03002; FUSION; SAFETY;

D O I：

10.1111/cen.12240

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Daily recombinant growth hormone (GH) restores normal growth and body composition in GH-deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children. Developing long-acting GH formulations has proved challenging, and questions remain regarding safety and efficacy. In this review, we focus on the rationale for generating long-acting GH agonists and the technologies being developed to deliver prolonged exposure to GH.

引用

页码：305 / 309

页数：5

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