Deriving dopaminergic neurons for clinical use. A practical approach

被引：38
|
作者：
Gonzalez, Rodolfo [1 ]
Garitaonandia, Ibon [1 ]
Abramihina, Tatiana [1 ]
Wambua, Gerald K. [1 ]
Ostrowska, Alina [1 ]
Brock, Mathew [2 ]
Noskov, Alexander [1 ]
Boscolo, Francesca S. [3 ,4 ]
Craw, John S. [1 ]
Laurent, Louise C. [4 ]
Snyder, Evan Y. [5 ]
Semechkin, Ruslan A. [1 ]
机构：
[1] Int Stem Cell Corp, Carlsbad, CA 92008 USA
[2] Axion Biosyst, Atlanta, GA 30332 USA
[3] Scripps Res Inst, Dept Physiol Chem, Ctr Regenerat Med, La Jolla, CA 92037 USA
[4] Univ Calif San Diego, Dept Reprod Med, San Diego, CA 92035 USA
[5] Sanford Burnham Med Res Inst, Stem Cell & Regenerat Program, La Jolla, CA 92037 USA
来源：
SCIENTIFIC REPORTS | 2013年 / 3卷
关键词：
PLURIPOTENT STEM-CELLS; DIFFERENTIATION;
D O I：
10.1038/srep01463
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.
引用
收藏
页数：5
相关论文
共 50 条
  • [41] Adolescent drug use. Ethical dilemma in the diagnostic-therapeutic approach
    Matali Costa, J. L.
    Pardo Gallego, M.
    Trenchs Sainz de la Maza, V.
    Serrano Troncoso, E.
    Gabaldon Fraile, S.
    Luaces Cubells, C.
    ANALES DE PEDIATRIA, 2009, 70 (04): : 386 - 390
  • [42] Susceptibility profiles of Malassezia species against antifungal drugs of clinical use.
    Rojas, Florencia
    Sosa, Maria
    Mussin, Javier
    Angiolella, Letizia
    Giusiano, Gustavo
    MEDICAL MYCOLOGY, 2018, 56 : S86 - S86
  • [43] Value of negative skin tests to benzylpenicillin and semisynthetic penicillins in clinical use.
    Melanson, M
    SilviuDan, F
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (01) : 254 - 254
  • [44] Clinical experience with Tolvaptan outpatient use. Cost and effectiveness in 9 cases
    Barajas-Galindo, David E.
    Vidal-Casariego, Alfonso
    Gomez-Hoyos, Emilia
    Guerra-Gonzalez, Maria
    GACETA MEDICA DE MEXICO, 2020, 156 (01): : 76 - 79
  • [45] Analysis of discoloration of intravenous filter membranes during simulated clinical use.
    Goggin, M
    Costello, I
    Huxtable, S
    Maynard, E
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2000, 59 : 182A - 182A
  • [46] Quantitative 133Xe SPECT in normal population:: T-score analysis as a primary approach for clinical use.
    Slosman, DO
    Chicherio, C
    Ludwig, C
    De Ribaupierre, S
    Genton, L
    De Ribaupierre, A
    Pichard, C
    Mayer, E
    Annoni, JM
    JOURNAL OF NUCLEAR MEDICINE, 2001, 42 (05) : 236P - 236P
  • [47] The curcuma antioxidants:: pharmacological effects and prospects for future clinical use.: A review
    Miquel, J
    Bernd, A
    Sempere, JM
    Díaz-Alperi, J
    Ramírez, A
    ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2002, 34 (01) : 37 - 46
  • [48] Studies of the off-responses of the human VECP and their potential clinical use.
    Mizunoya, S
    Nakamura, T
    Uehara, J
    Mizota, A
    Adachi-Usami, E
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2001, 42 (04) : S788 - S788
  • [49] Impact of pediatric epilepsy on the family: A new scale for clinical and research use.
    Camfield, C
    Breau, L
    Camfield, P
    EPILEPSIA, 1999, 40 : 214 - 214
  • [50] Pathological PC/internet use. Clinical issues, diagnostic and therapeutic approaches
    Schuhler, Petra
    Vogelgesang, Monika
    Petry, Joerg
    PSYCHOTHERAPEUT, 2009, 54 (03): : 187 - 192
12345