Transition-metal-free synthesis of multisubstituted N-arylindoles via reaction of arynes and α-amino ketones

被引：28
|
作者：
He, Lin [1 ]
Pian, Ji-Xin [1 ]
Shi, Jun-Feng [1 ]
Du, Guang-Fen [1 ]
Dai, Bin [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832000, Xinjiang Uygur, Peoples R China
来源：
TETRAHEDRON | 2014年 / 70卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Indoles; Arynes; Cross-coupling reaction; alpha-Amino ketones; SIMPLE INDOLE ALKALOIDS; EFFICIENT SYNTHESIS; OXIDATIVE CYCLIZATION; BOND; BENZYNE; CONSTRUCTION; AMINATION; ARYLATION; CASCADE;
D O I：
10.1016/j.tet.2014.02.028
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple transition-metal-free protocol for the synthesis of indoles has been developed using aryne cycloaddition. The in situ-generated arynes couple with alpha-amino ketones through a one-step N-arylation-nucleophilic addition process under mild conditions and efficiently produce multi-substituted N-arylindoles. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2400 / 2405
页数：6
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