New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.

被引：21

作者：

Yang, Bin ^{[1
,2
]}

Zhou, Xuefeng ^{[1
,2
]}

Huang, Hui ^{[1
]}

Yang, Xian-Wen ^{[1
,2
]}

Liu, Juan ^{[1
,2
]}

Lin, Xiuping ^{[1
,2
]}

Li, Xiubao ^{[1
]}

Peng, Yan ^{[1
,2
]}

Liu, Yonghong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

[2] Chinese Acad Sci, S China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China

来源：

MARINE DRUGS | 2012年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Sinularia sp; cembrane diterpenoids; NF-kappa B inhibitor; OXYGENATED CEMBRANOIDS; A-I; FLEXIBILIS; CRASSA; QUERCIFORMIS; GIBBEROSA; CAPILLOSA; GRANOSA;

D O I：

10.3390/md10092023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new cembrane diterpenoids, named sinuflexibilins A-E (1-5), along with nine other known diterpenoids (6-14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-kappa B activation using the cell-based HEK293 NF-kappa B luciferase reporter gene assay.

引用

页码：2023 / 2032

页数：10

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