Regulation and function of mammalian DNA methylation patterns: a genomic perspective

被引：30

作者：

Wu, Hao ^{[1
]}

Tao, Jifang ^{[2
]}

Sun, Yi Eve ^{[3
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Labs Drs Kenneth Chien, Cambridge, MA 02138 USA

[2] MIT, HHMI, Dr Mark Bears Lab, Cambridge, MA 02139 USA

[3] Univ Calif Los Angeles, Los Angeles, CA 90024 USA

来源：

BRIEFINGS IN FUNCTIONAL GENOMICS | 2012年 / 11卷 / 03期

关键词：

DNA methylation; DNA methyltransferases; Tet DNA hydroxylases; Polycomb repression; promoter and non-promoter DNA methylation; epigenomics; methylome; ACTIVITY-INDUCED GADD45B; DE-NOVO METHYLATION; CELL SELF-RENEWAL; METHYLTRANSFERASE DNMT3A; BINDING PROTEIN; WIDE ANALYSIS; CPG ISLANDS; HISTONE H3; EPIGENETIC INHERITANCE; GENE-EXPRESSION;

D O I：

10.1093/bfgp/els011

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA methylation patterns that are required for proper epigenetic regulation of gene expression and maintenance of genome stability during normal development. Aberrant DNA methylation patterns are implicated in a variety of pathological conditions including cancer and neurological disorders. Rapid advances in genomic technologies have allowed the generation of high resolution whole-genome views of DNA methylation and DNA methyltransferase occupancy in pluripotent stem cells and differentiated somatic cells. Furthermore, recent identification of oxidation derivatives of cytosine methylation in mammalian DNA raises the possibility that DNA methylation patterns are more dynamic than previously anticipated. Here, we review the recent progress in our understanding of the genomic function and regulatory mechanisms of mammalian DNA methylation.

引用

页码：240 / 250

页数：11

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