Catalyst-free synthesis of benzofuran-fused pyrido [4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions

被引：10
|
作者：
Li, Bo [1 ,2 ]
Yue, Zhizhou [1 ]
Xiang, Haoyue [2 ]
Lv, Linlin [1 ]
Song, Shanshan [2 ]
Miao, Zehong [2 ]
Yang, Chunhao [2 ]
机构：
[1] Wuhan Univ Technol, Sch Chem Engn, Dept Pharmaceut Engn, Wuhan 430070, Hubei, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
RSC ADVANCES | 2014年 / 4卷 / 01期
基金：
中国国家自然科学基金;
关键词：
CASCADE REACTIONS; TOPOISOMERASE-I; INHIBITORS; DISCOVERY; POTENT; ACID; IDENTIFICATION; CONSTRUCTION; DERIVATIVES; ANTITUMOR;
D O I：
10.1039/c3ra44828b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A rapid, one-pot, catalyst-free approach to novel benzofuran-fused pyrido[4,3-d]pyrimidines with good antitumor activities via a cascade SNAr/cyclization/condensation reaction through 2-(2-hydroxyphenyl) acetonitriles and 4,6-dichloropyrimidine-5-carbaldehyde was developed.
引用
收藏
页码：358 / 364
页数：7
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