The relationship between Lp-PLA2 level and severity coronary artery disease in patient with acute coronary syndrome

Background: Inflammation is one of the factors playing role in acute coronary syndrome (ACS). Many independent evaluation studies have been published verifying the role of inflammation in atherogenesis and supporting the opinion that lipoprotein-associated phospholipase A2 (Lp-PLA2) is a cardiovascular risk indicator which is independent from classical risk factors. In this study, serum Lp-PLA2 level in patients who were hospitalized with prediagnosis of high risk ACS and relationship between Lp-PLA2 level and coronary artery disease were investigated. Method: The study included 51 ACS patients. Patients were divided into two groups as Lp-PLA2 positive (mean age; 53 +/- 14 years) and negative(mean age; 58 +/- 9 years). Number of Lp-PLA2 positive patients was 17 and negative patients was 34. Routine biochemical parameters and Lp-PLA2 levels were performed. Results: There was not a significant difference between groups in terms of mean age, gender, smoking status. CKMB values was found signifcantly higher in Lp-PLA2 positive patient group. Although plasma CKMB level was predictive for high Lp-PLA2 value, Gensini score was not significantly predictive. Conclusion: A significant relationship could not be found between coronary artery disease severity estimated with Gensini score and serum Lp-PLA2 values.