Overexpression of thymic stromal lymphopoietin in allergic rhinitis

被引：82
|
作者：
Mou, Zhonglin [2 ]
Xia, Jiahong [3 ]
Tan, Yenong [2 ]
Wang, Xiangdong [1 ]
Zhang, Yuan [3 ]
Zhou, Bing [1 ]
Li, Huabin [1 ]
Han, Demin [1 ]
机构：
[1] Capital Med Univ, Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
[2] Hainan Prov Peoples Hosp, Dept Otolaryngol, Haikou, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Surg, Wuhan 430074, Peoples R China
来源：
ACTA OTO-LARYNGOLOGICA | 2009年 / 129卷 / 03期
关键词：
Allergic rhinitis; thymic stromal lymphopoietin; T cell; cytokine; interleukin-4; EPITHELIAL-CELLS; INFLAMMATION;
D O I：
10.1080/00016480802225884
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Conclusion. Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR. Objective. To evaluate the possible role of TSLP in the pathogenesis of AR. Patients and methods. We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA). Results. TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P0.05).
引用
收藏
页码：297 / 301
页数：5
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