RETRACTED: Evaluation of amorphous debranched starch as extended-release matrices in tablets (Retracted Article)

被引：10
|
作者：
Liu, Guodong [1 ]
Hong, Yan [1 ]
Gu, Zhengbiao [1 ]
机构：
[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2013年 / 98卷 / 01期
关键词：
Amorphous debranched starch; Pullulanase; Tablet; Extended release; Excipient; WAXY MAIZE STARCH; RICE STARCH; DRUG-RELEASE; RHEOLOGICAL PROPERTIES; PHYSICAL MODIFICATION; DIGESTIBILITY; CRYSTALLIZATION; AMYLOSE; ENZYME;
D O I：
10.1016/j.carbpol.2013.05.097
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
This study aims to investigate the physicochemical and extended-release properties of amorphous debranched starch (ADBS) that is a linear short chain amylose derived from pullulanase enzymatic modification. The results show the completely amorphous ADBS was soluble in cold water, which developed into a disordered gel network at 25 degrees C. ADBS based tablets were able to extend drug release in different media. Drug release, which was accelerated by decreased pH and pancreatin, was barely affected by ionic strength. The kinetics of the drug release process that was dominated by Fickian diffusion was best fitted and interpreted by the Higuchi equation. The results indicate ADBS is an ideal hydrophilic excipient which extends the in vitro release of water-soluble drugs for 24h. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：995 / 1001
页数：7
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