Genomic DNA sequence and transcription factor binding sites of mouse Ninjurin

被引：4

作者：

Moon, AR

Oh, GT

Kim, JW

Choi, YJ

Choe, IS ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Biosci Res Div, Cell Biol Lab, KRIBB, Yusong 305600, Daejon, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Genet Resources Ctr, KRIBB, Yusong 305600, Daejon, South Korea

[3] Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea

来源：

DNA SEQUENCE | 2001年 / 12卷 / 5-6期

关键词：

Ninjurin; genomic DNA; promoter; transcription factor;

D O I：

10.3109/10425170109084463

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The complete genomic DNA sequence of mouse ninjurin gene has been cloned and sequenced by screening a bacterial artificial chromosome (BAC) library of mouse 129/SvJ genomic DNA. The mouse ninjurin gene comprises four exons and the translatable sequences are included in the first three exons. The putative promoter region of the mouse ninjurin gene lacks the consensus "CAAT" or "TATA" sequence. Nonetheless, it has demonstrated the promoter activity in transient transfection experiment using the construct containing putative promoter sequence of mouse ninjurin and reporter gene. The nucleotide sequence of the putative promoter region shows 83% homology with the corresponding DNA sequence of human ninjurin gene that had been previously reported, and reveals a high degree of conservation between the two species. Analysis of the DNA sequence identified the putative promoters and the binding sites for a variety of transcription factors of mouse ninjurin.

引用

页码：385 / 395

页数：11

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