Stem cell therapy for diabetes mellitus

被引：7

作者：

Voltarelli, Julio C. ^{[1
]}

Couri, Carlos E. B. ^{[1
]}

Oliveira, Maria C. ^{[1
]}

Moraes, Daniela A. ^{[1
]}

Stracieri, Ana B. P. L. ^{[1
]}

Pieroni, Fabiano ^{[1
]}

Barros, George M. N. ^{[1
]}

Malmegrim, Kelen C. R. ^{[1
]}

Simoes, Belinda P. ^{[1
]}

Leal, Angela M. O. ^{[2
]}

Foss, Milton C. ^{[1
]}

机构：

[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Clin Med, BR-14051140 Sao Paulo, Brazil

[2] Univ Fed Sao Carlos, Dept Med, BR-13560 Sao Carlos, SP, Brazil

来源：

KIDNEY INTERNATIONAL SUPPLEMENTS | 2011年 / 1卷 / 03期

关键词：

diabetes mellitus; hematopoietic stem cell; stem cell therapy;

D O I：

10.1038/kisup.2011.22

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, we present (1) a brief discussion of hematopoietic stem cell transplantation (HSCT) for severe and refractory autoimmune diseases (AIDs) from its beginning in 1996 through recently initiated prospective randomized clinical trials; (2) an update (up to July 2009) of clinical and laboratory outcomes of 23 patients with newly diagnosed type 1 diabetes mellitus (T1DM), who underwent autologous HSCT at the Bone Marrow Transplantation Unit of the Ribeirao Preto Medical School, University of Sao Paulo, Brazil; (3) a discussion of possible mechanisms of action of HSCT in AIDs, including preliminary laboratory data obtained from our patients; and (4) a discussion of future perspectives of stem cell therapy for T1DM and type 2 DM, including the use of stem cell sources other than adult bone marrow and the combination of cell therapy with regenerative compounds.

引用

页码：94 / 98

页数：5

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