Pulsed Dendritic Cells for the Therapy of Experimental Glioma

被引：3
|
作者：
Chekhonin, I. V. [1 ]
Gurina, O. I. [1 ]
Cherepanov, S. A. [2 ]
Abakumov, M. A. [2 ]
Ionova, K. P. [1 ]
Zhigarev, D. K. [1 ]
Makarov, A. V. [1 ]
Chekhonin, V. P. [1 ,2 ]
机构：
[1] Minist Hlth Russian Federat, VP Serbsky Fed Med Res Ctr Psychiat & Narcol, Moscow, Russia
[2] NI Pirogov Russian Natl Res Med Univ, Med Biol Fac, Dept Med Nanobiotechnol, Minist Hlth Russian Federat, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 06期
关键词：
dendritic cells; glioma; neurospecific proteins; angiogenesis; periglioma zone; MONOCLONAL-ANTIBODIES; C6; GLIOMA;
D O I：
10.1007/s10517-016-3512-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.
引用
收藏
页码：792 / 796
页数：5
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