Development of the Composition, Technology, and Standardization of Tablets Containing Dry Extract of Meadowsweet Filipendula Ulmaria (L.) Maxim.

被引：0
|
作者：
Shilova, I. V. [1 ,2 ]
Khoruzhaya, T. G. [1 ]
Samylina, I. A. [3 ]
机构：
[1] Siberian State Med Univ, Tomsk 634050, Russia
[2] Russian Acad Med Sci, Inst Pharmacol, Siberian Branch, Tomsk 634050, Russia
[3] Sechenov First Moscow State Med Univ, Moscow 119019, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 47卷 / 10期
关键词：
flavonoids; tablets with dry extract; standardization; meadowsweet (Filipendula ulmaria);
D O I：
10.1007/s11094-014-1003-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A commercially viable composition for tablets containing dry meadowsweet [Filipendula ulmaria (L.) Maxim.] extract was developed. A direct pressing method was proposed and product quality standards were defined based on a study of the processing properties of the dry plant extract and tableting mixtures. A combined method for both qualitative (TLC on silica gel, UV spectroscopy) and quantitative (differential spectrophotometry using quercetin State Standard Sample) was developed for determination of flavonoids in the tablets. Three batches of tablets satisfying all requirements of the State Pharmacopoeia XIth Ed. and Industry Standard 64.7.170 - 75 were manufactured based on the dry meadowsweet extract.
引用
收藏
页码：552 / 555
页数：4
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