Recentadvances in the development of peptide nucleic acid as a gene-targeted drug

被引：38

作者：

Marin, VL ^{[1
]}

Roy, S ^{[1
]}

Armitage, BA ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2004年 / 4卷 / 03期

关键词：

antigene; antisense; gene expression; hybridisation; peptide nucleic acid; PNA; telomerase; therapeutics;

D O I：

10.1517/14712598.4.3.337

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptide nucleic acid (PNA) is a non-ionic mimic of DNA that binds to complementary DNA and RNA sequences with high affinity and selectivity. Targeting of single-stranded RNA leads,to antisense effects, whereas PNAs directed toward double-stranded DNA exhibit antigene properties. Recent advances in cell uptake and in antisense and antigene effects in biological systems are summarised in this review. in addition to traditional targets, namely genomic DNA and messenger RNA, applications for PNA as a bacteriocidal antibiotic, for regulating splice site selection and as a telomerase inhibitor are described.

引用

页码：337 / 348

页数：12

共 50 条

[31] Generation of the keratocan gene-targeted mutagenesis in the mouse
Liu, CY
Hassel, HR
Kane, B
Doetschman, TC
Kao, WWY
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U828 - U828
[32] Oligonucleotides as the basis of gene-targeted therapeutic drugs
Vlasov, VV
HERALD OF THE RUSSIAN ACADEMY OF SCIENCES, 2004, 74 (03) : 283 - 286
[33] Hybrid Nucleic Acid Nanocapsules for Targeted, Enzyme-Specific Drug Delivery and Intracellular Gene Regulation
Santiana, Joshua J.
Gudipati, Saketh
Hartmann, Alyssa K.
Rouge, Jessica L.
TARGETED NANOSYSTEMS FOR THERAPEUTIC APPLICATIONS: NEW CONCEPTS, DYNAMIC PROPERTIES, EFFICIENCY, AND TOXICITY, 2019, 1309 : 59 - 77
[34] Gene-targeted therapies for the central nervous system
Miller, Timothy M.
Smith, Richard A.
Kordasiewicz, Holly
Kaspar, Brian K.
ARCHIVES OF NEUROLOGY, 2008, 65 (04) : 447 - 451
[35] Gene-targeted approaches to anxiety disorders and their therapy
Möhler, H
Fritschy, JM
Benke, D
Rudolph, U
Lüscher, B
Crestani, F
JOURNAL OF NEUROCHEMISTRY, 1999, 73 : S54 - S54
[36] Targeted Inactivation of the CCR5 Gene via Peptide Nucleic Acid-Induced Homologous Recombination
Schleifman, Erica
REJUVENATION RESEARCH, 2011, 14 (06) : 689 - 690
[37] ATTENUATION OF RENAL FIBROSIS AND INFLAMMATION IN NATRIURETIC PEPTIDE RECEPTOR A GENE-TARGETED MICE BY EPIGENETIC MECHANISMS OF SODIUM BUTYRATE-AND RETINOIC ACID
不详
JOURNAL OF INVESTIGATIVE MEDICINE, 2016, 64 (02) : 488 - 488
[38] Obstacles and Approaches to the Development of Gene Therapy and Nucleic Acid-based Drug Foreword
Shimizu, Kahori
Ando, Mitsuru
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2012, 132 (12): : 1371 - 1372
[39] Targeted gene regulation by an enzyme degradable nucleic acid nanocapsule
Hartmann, Alyssa
Cairns-Gibson, Dominic
Barber, Halle
Rouge, Jessica
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
[40] Imaging gene expression in the brain with peptide nucleic acid (PNA) antisense radiopharmaceuticals and drug targeting technology
Boado, RJ
Pardridge, WM
LETTERS IN PEPTIDE SCIENCE, 2003, 10 (3-4): : 169 - 190

← 1 2 3 4 5 →