Characterization of polymeric system for cisplatin delivery - analytical methods for Pt determination

被引：1
|
作者：
Stoyanova, Ekaterina V. [1 ,3 ]
Karadjova, Irina B. [1 ]
Karadjov, Methody G. [2 ]
Koseva, Neli S. [3 ]
机构：
[1] Sofia Univ St Kliment Ohridski, Fac Chem & Pharm, Sofia 1164, Bulgaria
[2] Bulgarian Acad Sci, Inst Geol, BU-1113 Sofia, Bulgaria
[3] Bulgarian Acad Sci, Inst Polymers, BU-1113 Sofia, Bulgaria
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2013年 / 11卷 / 09期
关键词：
Pt; ETAAS; ICP-OES; Polymer drug; Phosphate buffered saline; ATOMIC-ABSORPTION-SPECTROMETRY; EMISSION-SPECTROMETRY; ENVIRONMENTAL MATERIALS; RADICAL POLYMERIZATION; PLATINUM; PRECONCENTRATION; TRACE;
D O I：
10.2478/s11532-013-0278-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed.
引用
收藏
页码：1548 / 1553
页数：6
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