Characterization of polymeric system for cisplatin delivery - analytical methods for Pt determination

被引：1
|
作者：
Stoyanova, Ekaterina V. [1 ,3 ]
Karadjova, Irina B. [1 ]
Karadjov, Methody G. [2 ]
Koseva, Neli S. [3 ]
机构：
[1] Sofia Univ St Kliment Ohridski, Fac Chem & Pharm, Sofia 1164, Bulgaria
[2] Bulgarian Acad Sci, Inst Geol, BU-1113 Sofia, Bulgaria
[3] Bulgarian Acad Sci, Inst Polymers, BU-1113 Sofia, Bulgaria
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2013年 / 11卷 / 09期
关键词：
Pt; ETAAS; ICP-OES; Polymer drug; Phosphate buffered saline; ATOMIC-ABSORPTION-SPECTROMETRY; EMISSION-SPECTROMETRY; ENVIRONMENTAL MATERIALS; RADICAL POLYMERIZATION; PLATINUM; PRECONCENTRATION; TRACE;
D O I：
10.2478/s11532-013-0278-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed.
引用
收藏
页码：1548 / 1553
页数：6
相关论文
共 50 条
  • [1] Biodegradable polymeric system for cisplatin delivery: Development, in vitro characterization and investigation of toxicity profile
    Alam, Noor
    Khare, Vaibhav
    Dubey, Ravindra
    Saneja, Ankit
    Kushwaha, Manoj
    Singh, Gurdarshan
    Sharma, Neelam
    Chandan, Balkrishan
    Gupta, Prem N.
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 38 : 85 - 93
  • [2] Polymeric vehicles for topical delivery and related analytical methods
    Cho, Heui Kyoung
    Cho, Jin Hun
    Jeong, Seong Hoon
    Cho, Dong Chul
    Yeum, Jeong Hyun
    Cheong, In Woo
    ARCHIVES OF PHARMACAL RESEARCH, 2014, 37 (04) : 423 - 434
  • [3] Polymeric vehicles for topical delivery and related analytical methods
    Heui Kyoung Cho
    Jin Hun Cho
    Seong Hoon Jeong
    Dong Chul Cho
    Jeong Hyun Yeum
    In Woo Cheong
    Archives of Pharmacal Research, 2014, 37 : 423 - 434
  • [4] Analytical methods for the determination of folic acid in a polymeric micellar carrier
    Andrisano, V
    Bartolini, M
    Bertucci, C
    Cavrini, V
    Luppi, B
    Cerchiara, T
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 32 (4-5) : 983 - 989
  • [5] PHYSICOCHEMICAL CHARACTERIZATION OF A POLYMERIC INJECTABLE IMPLANT DELIVERY SYSTEM
    SHIVELY, ML
    COONTS, BA
    RENNER, WD
    SOUTHARD, J
    BENNETT, AT
    JOURNAL OF CONTROLLED RELEASE, 1995, 33 (02) : 237 - 243
  • [6] Analytical methodologies for the determination of cisplatin
    Espinosa Bosch, M.
    Ruiz Sanchez, A. J.
    Sanchez Rojas, F.
    Bosch Ojeda, C.
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 47 (03) : 451 - 459
  • [7] A cross-linked polymeric micellar delivery system for cisplatin(IV) complex
    Song, Haiqin
    Wang, Rui
    Xiao, Haihua
    Cai, Haidong
    Zhang, Wenjing
    Xie, Zhigang
    Huang, Yubin
    Jing, Xiabin
    Liu, Tongjun
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 83 (01) : 63 - 75
  • [8] DETERMINATION OF CISPLATIN LOADED TO POLYMERIC SYSTEMS
    EGEA, MA
    VALERO, J
    GIRONA, MV
    GARCIA, ML
    ANALUSIS, 1993, 21 (09) : 373 - 377
  • [9] Introduction of cisplatin into polymeric micelle Delivery Systems
    J Control Release, 2-3 (351):
  • [10] Development, Optimization and Characterization of Nanoparticle Drug Delivery System of Cisplatin
    Agrahari, V.
    Kabra, V.
    Trivedi, P.
    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3, 2009, 23 (1-3): : 1325 - +
12345