Synthesis of Dimethylphosphinyl-substituted α-Amino(aryl)methylphosphonic Acids and Their Esters

被引：4

作者：

Zagraniarsky, Yulian ^{[1
]}

Ivanova, Bojidarka ^{[1
]}

Nikolov, Karamfil ^{[1
]}

Varbanov, Sabi ^{[2
]}

Cholakova, Tsvetanka ^{[1
]}

机构：

[1] Univ Sofia, Fac Chem, Sofia 1164, Bulgaria

[2] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2008年 / 63卷 / 10期

关键词：

Dimethylphosphinyl-substituted Phosphonates and alpha-Aminophosphonic Acids; Kabachnik-Fields Reaction; Imine Hydrophosphonylation;

D O I：

10.1515/znb-2008-1009

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Dimethylphosphinylmethylamine (1) and its aldimines 2 Were used for the preparation of dimethyl and diethyl alpha-amino(aryl)methylphosphonates 3a-1 via imine hydrophosphonylation and Kabachnik-Fields reaction. Their acid hydrolysis gave rise to the corresponding alpha-aminophosphonic acids 4a-e. Compounds 3 and 4 have two different phosphorus-containing groups-phosphonyl and dimethylphosphinyl-and might have interesting biological activity.

引用

页码：1192 / 1198

页数：7

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