[1] Univ Porto, Fac Pharm, Dept Drug Sci, UCIBIO,REQUIMTE,MEDTECH,Lab Pharmaceut Technol, Porto, Portugal
[2] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal
[3] Fernando Pessoa Univ, Fac Hlth Sci, CEBIMED Biomed Res Ctr, FPENAS UFP Energy Environm & Hlth Res Unit, Porto, Portugal
[4] Univ Coimbra, Fac Pharm FFUC, Coimbra, Portugal