IDH1 and IDH2 Mutations in Gliomas

被引：450
|
作者：
Cohen, Adam L. [1 ]
Holmen, Sheri L. [2 ]
Colman, Howard [3 ]
机构：
[1] Univ Utah, Huntsman Canc Inst, Dept Internal Med, Div Med Oncol, Salt Lake City, UT 84112 USA
[2] Univ Utah, Huntsman Canc Inst, Dept Surg, Salt Lake City, UT 84112 USA
[3] Univ Utah, Huntsman Canc Inst, Dept Neurosurg, Salt Lake City, UT 84112 USA
来源：
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2013年 / 13卷 / 05期
关键词：
Isocitrate dehydrogenase; Astrocytoma; Oligodendroglioma; Glioblastoma; 2-Hydroxyglutarate; Carcinogenesis; Prognosis; Mutations; INTEGRATED GENOMIC ANALYSIS; HIGH-GRADE GLIOMAS; CODON; 132; MUTATION; ISOCITRATE DEHYDROGENASE; MAFFUCCI SYNDROME; OLLIER DISEASE; IN-VIVO; GLIOBLASTOMA; TUMORS; LEUKEMIA;
D O I：
10.1007/s11910-013-0345-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a possible oncometabolite, and to not produce NADPH. IDH mutations are oncogenic, although whether the mechanism is through alterations in hydroxylases, redox potential, cellular metabolism, or gene expression is not clear. The mutations also drive increased methylation in gliomas. Gliomas with mutated IDH1 and IDH2 have improved prognosis compared with gliomas with wild-type IDH. Mutated IDH can now be detected by immunohistochemistry and magnetic resonance spectroscopy. No drugs currently target mutated IDH, although this remains an area of active research.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] IDH1 and IDH2 mutations in diffusely infiltrating gliomas: distribution, mutation frequencies and clinical consequences
    Hartmann, C.
    von Deimling, A.
    ACTA NEUROPATHOLOGICA, 2009, 118 (03) : 443 - 443
  • [32] IDH1 mutations in gliomas
    Ohgaki, H.
    Watanabe, T.
    Nobusawa, S.
    Kleihues, P.
    VIRCHOWS ARCHIV, 2009, 455 : 21 - 21
  • [33] Comparing the Oncogenic Effects of IDH1 and IDH2 Mutations in Chondrosarcoma
    Phillips, Jenny
    Stacey, Michael
    Osgood, Christopher
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2023, 59 : S106 - S107
  • [34] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies
    K Oki
    J Takita
    M Hiwatari
    R Nishimura
    M Sanada
    J Okubo
    M Adachi
    M Sotomatsu
    A Kikuchi
    T Igarashi
    Y Hayashi
    S Ogawa
    Leukemia, 2011, 25 : 382 - 384
  • [35] IDH1/IDH2 mutations predict survival in glioma and AML
    Hegi, M.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S2 - S2
  • [36] IDH1 and IDH2 mutations in Bulgarian patients with glial tumours
    Goranova, T.
    Stancheva, G.
    Mitkova, A.
    Kaneva, R.
    Poptodorov, G.
    Velinov, N.
    Mitev, V.
    Gabrovsky, N.
    EJC SUPPLEMENTS, 2010, 8 (05): : 224 - 225
  • [37] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies
    Oki, K.
    Takita, J.
    Hiwatari, M.
    Nishimura, R.
    Sanada, M.
    Okubo, J.
    Adachi, M.
    Sotomatsu, M.
    Kikuchi, A.
    Igarashi, T.
    Hayashi, Y.
    Ogawa, S.
    LEUKEMIA, 2011, 25 (02) : 382 - +
  • [38] Mutations in the Isocitrate Dehydrogenase Genes IDH1 and IDH2 in Tumors
    Schaap, Frank G.
    French, Pim J.
    Bovee, Judith V. M. G.
    ADVANCES IN ANATOMIC PATHOLOGY, 2013, 20 (01) : 32 - 38
  • [39] Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report
    Haider, Ali S.
    Ene, Chibawanye I.
    Palmisciano, Paolo
    Haider, Maryam
    Rao, Ganesh
    Ballester, Leomar Y.
    Fuller, Gregory N.
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [40] IDH1 and IDH2 hotspot mutations are not found in canine glioma
    Reitman, Zachary J.
    Olby, Natasha J.
    Mariani, Christopher L.
    Thomas, Rachael
    Breen, Matthew
    Bigner, Darell D.
    McLendon, Roger E.
    Yan, Hai
    INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (01) : 245 - 246
12345