Progression of liver fibrosis in post-transplant hepatitis C: Mechanisms, assessment and treatment

被引:108
|
作者
Berenguer, Marina [1 ,2 ]
Schuppan, Detlef [3 ,4 ]
机构
[1] Univ Valencia, Dept Med, Hepatol & Liver Transplantat Unit, La Fe Hosp, E-46003 Valencia, Spain
[2] Inst Salud Carlos III, Natl Network Ctr Hepatol & Gastroenterol Res, CIBEREHD, Madrid, Spain
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, D-55116 Mainz, Germany
[4] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02215 USA
关键词
Antifibrotic; Biopsy; Cirrhosis; Collagen; Elastography; Fibrosis; HCV; Hepatic stellate cell; Interferon; Liver; Macrophage; NAFLD; Post-transplant; Progression; Second hit; T cell; TGFbeta; Serum marker; Transplantation; VENOUS-PRESSURE GRADIENT; VIRUS CORE PROTEIN; OPEN-LABEL SERIES; SUSTAINED VIROLOGICAL RESPONSE; TRANSPLANT RECIPIENTS; ANTIVIRAL THERAPY; PEGYLATED-INTERFERON; TRANSIENT ELASTOGRAPHY; STELLATE CELLS; CLINICAL-IMPLICATIONS;
D O I
10.1016/j.jhep.2012.12.014
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Liver fibrosis results from an excessive wound healing response in most chronic liver diseases, such as hepatitis C. Despite great advances in antiviral therapy in recent years, progressive liver fibrosis remains a major problem for patients with recurrent hepatitis C after liver transplantation. Liver biopsy remains a central tool in the management of HCV-positive liver transplant recipients, but reliable non-invasive methods for the assessment of liver fibrosis, such as ultrasound elastography, are increasingly being incorporated in the management of post-transplant patients, helping predict prognosis, guide treatment decisions, and stratify patients for emerging antifibrotic therapies. In this manuscript, we will review the natural history as well as tools to monitor fibrosis progression in the HCV-positive liver transplant recipient, the mechanisms underlying rapid fibrosis progression in up to 30% of these patients, the effect of antiviral therapies and highlight promising antifibrotic approaches. (c) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1028 / 1041
页数:14
相关论文
共 50 条
  • [21] Successful treatment of post-transplant hepatitis C virus cirrhosis with dadatasvir and asunaprevir
    Ozaras, Resat
    Mete, Bilgul
    Yemisen, Mucahit
    Balkan, Ilker Inanc
    Alkan, Mustafa
    Tabak, Fehmi
    JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, 2015, 24 (03) : 393 - 394
  • [22] Impact of Hepatitis C Viremia on Post-Transplant Diabetes Mellitus Development in Liver Transplant Recipients.
    Klein, K.
    Nelson, J.
    Crowther, B.
    Guerra, C.
    Kincaide, E.
    Speeg, K. V.
    Alkhouri, N.
    Hall, R.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 870 - 870
  • [23] Evaluation of centrilobular fibrosis in post-transplant liver: Preliminary results
    Saunders, R.
    Abou-Beih, S.
    Masson, S.
    Oakley, F.
    Tiniakos, D.
    VIRCHOWS ARCHIV, 2016, 469 : S83 - S83
  • [24] Slower Fibrosis Progression Among Liver Transplant Recipients With Sustained Virological Response After Hepatitis C Treatment
    Habib, Shahid
    Meister, Edward
    Habib, Sana
    Murakami, Traci
    Walker, Courtney
    Rana, Abbas
    Shaikh, Obaid S.
    GASTROENTEROLOGY RESEARCH, 2015, 8 (05) : 237 - 246
  • [25] Adult post-transplant lymphoproliferative disease in the liver graft in patients with recurrent hepatitis C
    Kim, Robin D.
    Fujikawa, Takahisa
    Mizuno, Shugo
    Schwartz, Jason J.
    Sorensen, John B.
    Hemming, Alan W.
    Fujita, Shiro
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2011, 23 (07) : 559 - 565
  • [26] Effect of Interferon On Fibrosis Progression Among Liver Transplant Recipients With Hepatitis C.
    Habib, S.
    Meister, E.
    Rana, A.
    Obaid, S.
    TRANSPLANTATION, 2014, 98 : 708 - 708
  • [27] Impact of hepatitis C treatment on liver histology in post liver transplant patients
    Ghalib, Reem
    Levine, Cheryl D.
    Hollinger, F. B.
    Stribling, Rise
    Box, Terry D.
    Hutson, William
    Post, Anthony B.
    Joshi, Shobha N.
    Steephen, Anisha
    Weinstein, Jeffrey
    Mejia, Alejandro
    Cheng, Stephen
    GASTROENTEROLOGY, 2008, 134 (04) : A762 - A762
  • [28] Impact of Sirolimus Duration on Hepatitis C Related Fibrosis Progression in Liver Transplant Recipients
    Kim, M.
    Curry, M. P.
    Rogers, C. C.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (05) : 1356 - U20
  • [29] Impact of Liver Fibrosis in Patients with Post-Liver Transplant Hepatitis C Recurrence.
    Gallegos-Orozco, Juan F.
    Yosephy, Amir
    Noble, Brie
    De Patris, Giovanni
    Aqel, Bashar A.
    Byrne, Thomas J.
    Carey, Elizabeth J.
    Douglas, David D.
    Reddy, Kunam S.
    Rakela, Jorge
    Vargas, Hugo E.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 377 - 377
  • [30] Assessment of Liver Fibrosis in Hepatitis C (HCV)-infected Kidney Transplant Candidates
    Barlass, Usman
    Mitchell, Justin
    Shah, Nikunj
    Aloman, Costica
    Eswaran, Sheila
    Reau, Nancy
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2017, 112 : S560 - S561