Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility

被引：19

作者：

Petrik, Jozsef ^{[1
]}

Verbanac, Donatella ^{[1
]}

Fabijanec, Marija ^{[1
]}

Hulina-Tomaskovic, Andrea ^{[1
]}

Ceri, Andrea ^{[1
]}

Somborac-Bacura, Anita ^{[1
]}

Petlevski, Roberta ^{[1
]}

Grdic Rajkovic, Marija ^{[1
]}

Rumora, Lada ^{[1
]}

Kruslin, Bozo ^{[2
,3
]}

Stefanovic, Mario ^{[1
,4
]}

Ljubicic, Neven ^{[2
,5
,6
]}

Barsic, Neven ^{[2
,5
]}

Hanzek, Antonija ^{[7
]}

Bockor, Luka ^{[8
]}

Celap, Ivana ^{[1
]}

Demirovic, Alma ^{[3
,6
]}

Barisic, Karmela ^{[1
]}

机构：

[1] Univ Zagreb, Fac Pharm & Biochem, Dept Med Biochem & Hematol, Ante Kovacica 1, Zagreb 10000, Croatia

[2] Univ Zagreb, Sch Med, Salata 3, Zagreb 10000, Croatia

[3] Univ Zagreb, Univ Hosp Ctr Sestre Milosrdnice, Dept Pathol & Cytol Ljudevit Jurak, Vinogradska 29, Zagreb 10000, Croatia

[4] Univ Zagreb, Univ Hosp Ctr Sestre milosrdnice, Dept Clin Chem, Vinogradska 29, Zagreb, Croatia

[5] Univ Zagreb, Univ Hosp Ctr Sestre Milosrdnice, Div Gastroenterol & Hepatol, Dept Internal Med, Vinogradska 29, Zagreb 10000, Croatia

[6] Univ Zagreb, Sch Dent Med, Gunduliceva 5, Zagreb 10000, Croatia

[7] Univ Nimes, UPR CHROME, 7 Pl Gabriel Peri, F-30000 Nimes, France

[8] Inst Anthropol Res, Ctr Appl Bioanthropol, Ljudevita Gaja 32, Zagreb 10000, Croatia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 21期

关键词：

colorectal cancer; liquid biopsy; circulating tumor cells; CTC clusters; viable CTCs; isolation techniques; detection methods; clinical utility; PERIPHERAL-BLOOD; LIQUID BIOPSY; CHEMOTHERAPY; SURVIVAL; THERAPY; PROGRESSION; EXPRESSION; COHORT;

D O I：

10.3390/ijms232113582

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor metastases. The analysis of circulating tumor cells (CTCs) and CTC clusters in the blood can be used for the early detection of invasive cancer. Moreover, CTCs have a prognostic significance in the monitoring of a malignant disease or the response to chemotherapy. This work presents an overview of the research conducted on CTCs with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with CRC.

引用

页数：18

共 50 条

[41] The Clinical Potential of Circulating Tumor Cells and Circulating Tumor-Associated Cellular Elements in Colorectal Cancer
Wang, Judy S.
Foote, Michael B.
Jazieh, Khalid A.
Diaz, Luis A., Jr.
CURRENT COLORECTAL CANCER REPORTS, 2013, 9 (04) : 303 - 311
[42] Clinical and biological significance of circulating tumor cells, circulating tumor DNA, and exosomes as biomarkers in colorectal cancer
Jia, Shiyu
Zhang, Rui
Li, Ziyang
Li, Jinming
ONCOTARGET, 2017, 8 (33) : 55632 - 55645
[43] Unraveling the potential clinical utility of circulating tumor DNA detection in colorectal cancer-evaluation in a nationwide Danish cohort
Henriksen, T., V
Demuth, C.
Frydendahl, A.
Nors, J.
Nesic, M.
Rasmussen, M. H.
Reinert, T.
Larsen, O. H.
Jaensch, C.
Love, U. S.
Andersen, P., V
Kolbro, T.
Thorlacius-Ussing, O.
Monti, A.
Goegenur, M.
Kildsig, J.
Bondeven, P.
Schlesinger, N. H.
Iversen, L. H.
Gotschalck, K. A.
Andersen, C. L.
ANNALS OF ONCOLOGY, 2024, 35 (02) : 229 - 239
[44] Postoperative Detection of Circulating Tumor Cells Predicts Tumor Recurrence in Colorectal Cancer Patients
Galizia, Gennaro
Gemei, Marica
Orditura, Michele
Romano, Ciro
Zamboli, Anna
Castellano, Paolo
Mabilia, Andrea
Auricchio, Annamaria
De Vita, Ferdinando
Del Vecchio, Luigi
Lieto, Eva
JOURNAL OF GASTROINTESTINAL SURGERY, 2013, 17 (10) : 1809 - 1818
[45] Postoperative Detection of Circulating Tumor Cells Predicts Tumor Recurrence in Colorectal Cancer Patients
Gennaro Galizia
Marica Gemei
Michele Orditura
Ciro Romano
Anna Zamboli
Paolo Castellano
Andrea Mabilia
Annamaria Auricchio
Ferdinando De Vita
Luigi Del Vecchio
Eva Lieto
Journal of Gastrointestinal Surgery, 2013, 17 : 1809 - 1818
[46] Using circulating tumor cells to inform on prostate cancer biology and clinical utility
Li, Jing
Gregory, Simon G.
Garcia-Blanco, Mariano A.
Armstrong, Andrew J.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2015, 52 (04) : 191 - 210
[47] Circulating tumor cells in colorectal cancer patients
Torino, Francesco
Bonmassar, Enzo
Bonmassar, Laura
De Vecchis, Liana
Barnabei, Agnese
Zuppi, Cecilia
Capoluongo, Ettore
Aquino, Angelo
CANCER TREATMENT REVIEWS, 2013, 39 (07) : 759 - 772
[48] Detection of RAS mutations in circulating tumor cells: applications in colorectal cancer and prospects
Denis, Jerome Alexandre
Lacorte, Jean-Marc
ANNALES DE BIOLOGIE CLINIQUE, 2017, 75 (06) : 607 - 618
[49] The detection of circulating tumor cells (CTCs) in patients with colorectal cancer by flow cytometry
Dilek, Y.
Simsek, E.
Carhan, A.
Terzi, E.
Calisir, E.
Tiryaki, M.
Pinarli, F.
Ozdemir, N.
Dede, D.
Yalcin, B.
Guler, O. O.
FEBS JOURNAL, 2016, 283 : 300 - 300
[50] Cytokeratin 20 improves the detection of circulating tumor cells in patients with colorectal cancer
Welinder, Charlotte
Jansson, Bo
Lindell, Gert
Wenner, Jorgen
CANCER LETTERS, 2015, 358 (01) : 43 - 46

← 1 2 3 4 5 →