Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility

被引：19

作者：

Petrik, Jozsef ^{[1
]}

Verbanac, Donatella ^{[1
]}

Fabijanec, Marija ^{[1
]}

Hulina-Tomaskovic, Andrea ^{[1
]}

Ceri, Andrea ^{[1
]}

Somborac-Bacura, Anita ^{[1
]}

Petlevski, Roberta ^{[1
]}

Grdic Rajkovic, Marija ^{[1
]}

Rumora, Lada ^{[1
]}

Kruslin, Bozo ^{[2
,3
]}

Stefanovic, Mario ^{[1
,4
]}

Ljubicic, Neven ^{[2
,5
,6
]}

Barsic, Neven ^{[2
,5
]}

Hanzek, Antonija ^{[7
]}

Bockor, Luka ^{[8
]}

Celap, Ivana ^{[1
]}

Demirovic, Alma ^{[3
,6
]}

Barisic, Karmela ^{[1
]}

机构：

[1] Univ Zagreb, Fac Pharm & Biochem, Dept Med Biochem & Hematol, Ante Kovacica 1, Zagreb 10000, Croatia

[2] Univ Zagreb, Sch Med, Salata 3, Zagreb 10000, Croatia

[3] Univ Zagreb, Univ Hosp Ctr Sestre Milosrdnice, Dept Pathol & Cytol Ljudevit Jurak, Vinogradska 29, Zagreb 10000, Croatia

[4] Univ Zagreb, Univ Hosp Ctr Sestre milosrdnice, Dept Clin Chem, Vinogradska 29, Zagreb, Croatia

[5] Univ Zagreb, Univ Hosp Ctr Sestre Milosrdnice, Div Gastroenterol & Hepatol, Dept Internal Med, Vinogradska 29, Zagreb 10000, Croatia

[6] Univ Zagreb, Sch Dent Med, Gunduliceva 5, Zagreb 10000, Croatia

[7] Univ Nimes, UPR CHROME, 7 Pl Gabriel Peri, F-30000 Nimes, France

[8] Inst Anthropol Res, Ctr Appl Bioanthropol, Ljudevita Gaja 32, Zagreb 10000, Croatia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 21期

关键词：

colorectal cancer; liquid biopsy; circulating tumor cells; CTC clusters; viable CTCs; isolation techniques; detection methods; clinical utility; PERIPHERAL-BLOOD; LIQUID BIOPSY; CHEMOTHERAPY; SURVIVAL; THERAPY; PROGRESSION; EXPRESSION; COHORT;

D O I：

10.3390/ijms232113582

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor metastases. The analysis of circulating tumor cells (CTCs) and CTC clusters in the blood can be used for the early detection of invasive cancer. Moreover, CTCs have a prognostic significance in the monitoring of a malignant disease or the response to chemotherapy. This work presents an overview of the research conducted on CTCs with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with CRC.

引用

页数：18

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